Allelic polymorphisms in the repeat and promoter regions of the interleukin-4 gene and malaria severity in Ghanaian children

被引：48

作者：

Gyan, BA

Goka, B

Cvetkovic, JT

Kurtzhals, JL

Adabayeri, V

Perlmann, H

Lefvert, AK

Akanmori, BD

Troye-Blomberg, M ^{[1
]}

机构：

[1] Stockholm Univ, Wenner Gren Inst, Dept Immunol, S-10691 Stockholm, Sweden

[2] Noguchi Mem Inst Med Res, Immunol Unit, Legon, Ghana

[3] Ghana Med Sch, Dept Child Hlth, Accra, Ghana

[4] Stockholm Univ, Dept Immunol, Stockholm, Sweden

[5] Karolinska Hosp, Res Immunol Unit, Ctr Mol Med, Stockholm, Sweden

[6] Univ Copenhagen, Copenhagen Univ Hosp, Ctr Med Parasitol, Dept Clin Microbiol, Copenhagen, Denmark

[7] Univ Copenhagen, Copenhagen Univ Hosp, Ctr Med Parasitol, Dept Infect Dis, Copenhagen, Denmark

来源：

CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2004年 / 138卷 / 01期

关键词：

falciparum; IgE; IL-4; polymorphism; pathogenesis; Plasmodium; severe malaria;

D O I：

10.1111/j.1365-2249.2004.02590.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Immunoglobulin E has been associated with severe malaria suggesting a regulatory role for interleukin (IL)-4 and/or IgE in the pathogenesis of severe malaria. We have investigated possible associations between polymorphisms in the IL-4 repeat region (intron 3) and promoter regions (IL-4 +33CT and - 590CT) in Ghanaian children with severe malaria. There was a significantly higher frequency of IL-4 intron-3 B1B1 genotype in the cerebral malaria group [P < 0.0001, odds ratio (OR) = 8.7]. The genotype and allele frequencies of the IL-4 -590 and +33 polymorphisms did not differ between the four study groups. Carriers of IL-4 +33T/-590T with cerebral malaria had elevated total IgE compared to non-carriers (P = 0.03). Our data suggest that IL-4 and/or IgE play a regulatory role in the pathogenesis of severe or complicated malaria.

引用

页码：145 / 150

页数：6

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[1] Population genetics -: Malaria susceptibility and CD36 mutation [J].