Biopharmaceutics of transmucosal peptide and protein drug administration: role of transport mechanisms with a focus on the involvement of PepT1

被引：25

作者：

Lee, VHL

Chu, C

Mahlin, ED

Basu, SK

Ann, DK

Bolger, MB

Haworth, IS

Yeung, AK

Wu, SK

Hamm-Alvarez, S

Okamoto, CT

机构：

[1] Univ So Calif, Sch Pharm, Dept Pharmaceut Sci, Los Angeles, CA 90033 USA

[2] Univ So Calif, Sch Pharm, Dept Mol Pharmacol & Toxicol, Los Angeles, CA 90033 USA

来源：

JOURNAL OF CONTROLLED RELEASE | 1999年 / 62卷 / 1-2期

关键词：

dipeptide transport; paracellular transport; endocytosis; PepT1; trafficking; modulation; structure-function;

D O I：

10.1016/S0168-3659(99)00030-9

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Non-invasive delivery of peptide and protein drugs will soon become a reality. This is due partly to a better understanding of the endogenous transport mechanisms, including paracellular transport, endocytosis, and carrier-mediated transport of mucosal routes of peptide and protein drug administration. This paper focuses on work related to the elucidation of structure-function, intracellular trafficking, and regulation of the intestinal dipeptide transporter, PepT1. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：129 / 140

页数：12

共 70 条

[1] Mapping the binding site pocket of the serotonin 5-hydroxytryptamine(2A) receptor - Ser(3.36(159)) provides a second interaction site for the protonated amine of serotonin but not of lysergic acid diethylamide or bufotenin [J].