A review of lipidomic technologies applicable to sphingolipidomics and their relevant applications

被引：49

作者：

Han, Xlanlin ^{[1
]}

Jiang, Xuntian ^{[1
]}

机构：

[1] Washington Univ, Sch Med, Dept Internal Med, Div Bioorgan Chem & Mol Pharmacol, St Louis, MO 63110 USA

来源：

EUROPEAN JOURNAL OF LIPID SCIENCE AND TECHNOLOGY | 2009年 / 111卷 / 01期

关键词：

Intrasource separation; Lipidomics; Multi-dimensional mass spectrometry; Sphingolipidomics; Shotgun lipidomics; TANDEM MASS-SPECTROMETRY; SIMULTANEOUS QUANTITATIVE-ANALYSIS; DATA-DEPENDENT ACQUISITION; BIOLOGICAL SAMPLES; SHOTGUN LIPIDOMICS; CELLULAR LIPIDOMES; ESI-MS/MS; MULTIPLE PRECURSOR; TARGETED LIPIDOMICS; DRUG DEVELOPMENT;

D O I：

10.1002/ejlt.200800117

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Sphingolipiclomics, a branch of lipidomics, focuses on the large-scale study of the cellular sphingolipidomes. In the current review, two main approaches for the analysis of cellular sphingolipidomes (i.e. LC-MS- or LC-MS/MS-based approach and shotgun lipidomics-based approach) are briefly discussed. Their advantages, some considerations of these methods, and recent applications Of these approaches are summarized. It is the authors' sincere hope that this review article will add to the readers understanding of the advantages and limitations of each developed method for die analysis of a cellular sphingolipidome.

引用

页码：39 / 52

页数：14

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