Is meditation associated with altered brain structure? A systematic review and meta-analysis of morphometric neuroimaging in meditation practitioners

被引:464
作者
Fox, Kieran C. R. [1 ]
Nijeboer, Savannah [1 ]
Dixon, Matthew L. [1 ]
Floman, James L. [2 ]
Ellamil, Melissa [1 ]
Rumak, Samuel P. [1 ]
Sedlmeier, Peter [3 ]
Christoff, Kalina [1 ,4 ]
机构
[1] Univ British Columbia, Dept Psychol, Vancouver, BC V6T IZ4, Canada
[2] Univ British Columbia, Dept Educ & Counselling Psychol & Special Educ, Vancouver, BC V6T IZ4, Canada
[3] Tech Univ Chemnitz, Inst Psychol, D-09111 Chemnitz, Germany
[4] Univ British Columbia, Brain Res Ctr, Vancouver, BC V6T 2B5, Canada
基金
加拿大健康研究院; 加拿大自然科学与工程研究理事会;
关键词
Meditation; Neuroimaging; Meta-analysis; Systematic review; Structural neuroimaging; Morphometric neuroimaging; Mindfulness; Anatomical likelihood estimation; Voxel based morphometry; Diffusion tensor imaging; Gray matter concentration; Mental practice; LONG-TERM MEDITATION; VOXEL-BASED MORPHOMETRY; WHITE-MATTER CHANGES; DEFAULT MODE NETWORK; ANTERIOR CINGULATE; ORBITOFRONTAL CORTEX; CORTICAL THICKNESS; COMPASSION MEDITATION; PREFRONTAL CORTEX; PAIN SENSITIVITY;
D O I
10.1016/j.neubiorev.2014.03.016
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
010107 [宗教学]; 030301 [社会学]; 070906 [古生物学及地层学(含古人类学)];
摘要
Numerous studies have begun to address how the brain's gray and white matter may be shaped by meditation. This research is yet to be integrated, however, and two fundamental questions remain: Is meditation associated with altered brain structure? If so, what is the magnitude of these differences? To address these questions, we reviewed and meta-analyzed 123 brain morphology differences from 21 neuroimaging studies examining similar to 300 meditation practitioners. Anatomical likelihood estimation (ALE) meta-analysis found eight brain regions consistently altered in meditators, including areas key to meta-awareness (frontopolar cortex/BA 10), exteroceptive and interoceptive body awareness (sensory cortices and insula), memory consolidation and reconsolidation (hippocampus), self and emotion regulation (anterior and mid cingulate; orbitofrontal cortex), and intra- and interhemispheric communication (superior longitudinal fasciculus; corpus callosum). Effect size meta-analysis (calculating 132 effect sizes from 16 studies) suggests a global 'medium' effect size (Cohen's (d) over bar = 0.46; (r) over bar = .19). Publication bias and methodological limitations are strong concerns, however. Further research using rigorous methods is required to definitively link meditation practice to altered brain morphology. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码:48 / 73
页数:26
相关论文
共 221 条
[1]
Remembering the past and imagining the future: Common and distinct neural substrates during event construction and elaboration [J].
Addis, Donna Rose ;
Wong, Alana T. ;
Schacter, Daniel L. .
NEUROPSYCHOLOGIA, 2007, 45 (07) :1363-1377
[2]
The anterior cingulate cortex - The evolution of an interface between emotion and cognition [J].
Allman, JM ;
Hakeem, A ;
Erwin, JM ;
Nimchinsky, E ;
Hof, P .
UNITY OF KNOWLEDGE: THE CONVERGENCE OF NATURAL AND HUMAN SCIENCE, 2001, 935 :107-117
[3]
Analayo Bh., 2003, Satipatthana: The Direct Path to Realization
[4]
Plasticity of Gray Matter Volume: The Cellular and Synaptic Plasticity That Underlies Volumetric Change [J].
Anderson, Brenda J. .
DEVELOPMENTAL PSYCHOBIOLOGY, 2011, 53 (05) :456-465
[5]
The Brain's Default Network and Its Adaptive Role in Internal Mentation [J].
Andrews-Hanna, Jessica R. .
NEUROSCIENTIST, 2012, 18 (03) :251-270
[6]
[Anonymous], 2013, PSYCHOL SCI
[7]
[Anonymous], NEUROIMAGE
[8]
[Anonymous], PLOS ONE
[9]
[Anonymous], VIJNANABHAIRVAVA
[10]
[Anonymous], NEUROSCI BIOBEHAV RE