Trilineage hematopoietic toxicity associated with valproic acid therapy

被引:12
作者
Bottom, KS
Adams, DM
Mann, KP
Ware, RE
机构
[1] DUKE UNIV,MED CTR,DEPT PEDIAT,DURHAM,NC 27710
[2] DUKE UNIV,MED CTR,DIV HEMATOL ONCOL,DURHAM,NC 27710
关键词
acute promyelocytic leukemia; valproic acid; hematopoietic toxicity;
D O I
10.1097/00043426-199701000-00011
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Purpose: Sodium valproate is commonly used as an anticonvulsant for patients with refractory epilepsy. Hematopoietic toxicity involving platelets or erythrocytes has been previously de scribed, as well as a few cases of generalized bone marrow suppression. Patients and Methods: We report an infant receiving sodium valproate who developed severe anemia and thrombocytopenia, numerous circulating immature myeloid cells, and a coagulopathy. Bone marrow aspirate revealed similar to 40% abnormal promyelocytes, and the initial clinical and pathologic interpretation was consistent with the diagnosis of acute promyelocytic leukemia. Results: Antineoplastic therapy was withheld while valproate was weaned. All hematopoietic abnormalities resolved after valproate therapy was discontinued. Conclusion: This report expands the clinical spectrum of hematopoietic toxicity associated with sodium valproate. Drug toxicity should be considered in any patient on valproate who develops hematopoietic abnormalities.
引用
收藏
页码:73 / 76
页数:4
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