Stem Cell Aging and Aberrant Differentiation within the Niche

被引：12

作者：

Choi, Jinkuk ^{[1
,2
]}

Artandi, Steven ^{[1
,2
]}

机构：

[1] Stanford Univ, Sch Med, Dept Med, Stanford, CA 94305 USA

[2] Stanford Univ, Sch Med, Canc Biol Program, Stanford, CA 94305 USA

来源：

CELL STEM CELL | 2009年 / 5卷 / 01期

关键词：

DNA-DAMAGE; AGE; MAINTENANCE; MECHANISMS; OLD;

D O I：

10.1016/j.stem.2009.06.006

中图分类号：

Q813 [细胞工程];

学科分类号：

100113 [医学细胞生物学];

摘要：

Stem cells age, but the underlying mechanisms remain unclear. In a recent issue of Cell, Inomata and colleagues (2009) show that DNA damage, a prime suspect in stem cell aging, causes graying and loss of melanocyte stem cells by inducing premature differentiation, without inducing apoptosis or senescence.

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收藏

页码：6 / 8

页数：3

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