Age-related upregulation of insulin-like growth factor receptor type I in rat cerebellum

被引：12

作者：

Chung, YH

Shin, CM

Joo, KM

Kim, MJ

Cha, CI

机构：

[1] Seoul Natl Univ, Dept Anat, Coll Med, Chongno Gu, Seoul 110799, South Korea

[2] Seoul Natl Univ, Neurosci Res Inst, Med Res Ctr, Chongno gu, Seoul 110799, South Korea

[3] KNIH, Biomed Brain Res Ctr, Seoul, South Korea

来源：

NEUROSCIENCE LETTERS | 2002年 / 330卷 / 01期

关键词：

insulin-like growth factor-I; insulin-like growth factor-I receptor; aging; cerebellum; rat; immunohistochemistry;

D O I：

10.1016/S0304-3940(02)00740-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We investigated age-related changes in insulin-like growth factor-I (IGF-I) receptor localization in the cerebellum using immunohistochemical staining. In adult rats, no immunoreactivity for IGF-I receptor was found in any layers of cerebellar cortex. In contrast, IGF-I receptor immunoreactivity was found in the cerebellar cortex of aged rats. The most prominent labeling was localized in the Purkinje cell layers and molecular layers. The cerebellar output neurons showed little immunoreactivity for IGF-I receptor in the nucleus medialis, interpositus and lateralis of adult rats. In aged cerebellar nuclei, IGF-I receptor immunoreactivity was observed in the surrounding neuropil. The first demonstration of upregulation of IGF-I receptor in aged rat cerebellum suggests that IGF-I may promote the survival of a degenerated population of the Purkinje neurons by increases in IGF-I receptor expression during aging. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：65 / 68

页数：4

共 19 条

[1] INSULIN-LIKE GROWTH-FACTOR I-IMMUNOREACTIVE PEPTIDE IN ADULT HUMAN CEREBELLAR PURKINJE-CELLS - COLOCALIZATION WITH LOW-AFFINITY NERVE GROWTH-FACTOR RECEPTOR [J].