Cholesterol in signal transduction

被引：196

作者：

Incardona, JP ^{[1
]}

Eaton, S

机构：

[1] Univ Washington, Dept Biol Struct, Seattle, WA 98195 USA

[2] Univ Washington, Ctr Dev Biol, Seattle, WA 98195 USA

[3] European Mol Biol Lab, Cell Biol Program, D-69117 Heidelberg, Germany

[4] Max Planck Inst Cell Biol & Genet, Dresden, Germany

来源：

CURRENT OPINION IN CELL BIOLOGY | 2000年 / 12卷 / 02期

关键词：

D O I：

10.1016/S0955-0674(99)00076-9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Membrane cholesterol impinges on signal transduction in several ways, which is highlighted in particular by the Hedgehog signaling pathway. In Hedgehog signaling, cholesterol is important for ligand biogenesis, as well as for signal transduction in receiving cells. Hedgehog ligands are post-translationally modified by cholesterol, and the Hedgehog receptor, Patched, is structurally similar to the Niemann-Pick C1 protein, which functions in intracellular lipid transport. Although the exact role of cholesterol in Hedgehog signal transduction remains elusive and is probably multifaceted, studies over the past year have implicated raft membrane subdomains, cholesterol transport and a link between protein and lipid trafficking in endocytic compartments.

引用

页码：193 / 203

页数：11

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