Natural pregnancies in HIV-serodiscordant couples receiving successful antiretroviral therapy

被引:87
作者
Barreiro, Pablo
del Romero, Jorge
Leal, Manuel
Hernando, Victoria
Asencio, Roman
de Mendoza, Carmen
Labarga, Pablo
Nunez, Marina
Ramos, Jose Tomas
Gonzalez-Lahoz, Juan
Soriano, Vincent
机构
[1] Hosp Carlos III, Dept Infect Dis, Madrid 28029, Spain
[2] Ctr Sanit Sandoval, Madrid, Spain
[3] Hosp Virgen Rocio, Seville, Spain
[4] Hosp 12 Octubre, E-28041 Madrid, Spain
关键词
antiretroviral therapy; HIV; sexual transmission; vertical transmission; viral load;
D O I
10.1097/01.qai.0000243091.40490.fd
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 [免疫学];
摘要
Increasing numbers of HIV-serodiscordant heterosexual couples are concerned about the chances for pregnancy. We reviewed all natural pregnancies attained by HIV-serodiscordant couples seen in 3 clinics in Spain, in which the infected partner had undetectable plasma viremia while receiving highly active antiretroviral therapy (HAART). In the case of HIV-infected mothers, only those with undetectable viremia during pregnancy and at delivery were chosen. A total of 62 HIV-scrodiscordant couples, 22 HIV-infected women (mean CD4 count of 522 cells/mu L, 55% hepatitis C virus [HCV]seropositive) and 40 HIV-infected men (mean CD4 count of 629 cells/mu L, 75% HCV-seropositive), were recorded. Overall, 76 natural pregnancies occurred, and 68 children were born. There were 9 fetal deaths, 1 twin pregnancy, 6 couples with 2 consecutive babies, and 4 couples with 3 consecutive newborns. There were no cases of HIV seroconversion in uninfected sexual partners. One case of vertical HIV transmission occurred, however. Serodiscordant couples attaining natural pregnancy are exposed to a negligible risk of sexual transmission of HIV when the infected partner presents with complete suppression of plasma viremia while receiving HAART.
引用
收藏
页码:324 / 326
页数:3
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