Modulation of neurotransmitter release by opioid mu- and kappa-receptors from adrenergic terminals in the myenteric plexus of the guinea-pig colon: Effect of alpha(2)-autoreceptor blockade

被引：11

作者：

Cosentino, M ^{[1
]}

Marino, F ^{[1
]}

Bombelli, R ^{[1
]}

Ferrari, M ^{[1
]}

Rasini, E ^{[1
]}

Giaroni, C ^{[1
]}

Lecchini, S ^{[1
]}

Frigo, G ^{[1
]}

机构：

[1] UNIV PAVIA,FAC MED 2,DEPT INTERNAL MED & THERAPEUT,I-21100 VARESE,VA,ITALY

来源：

NEUROSCIENCE LETTERS | 1997年 / 222卷 / 02期

关键词：

opioid receptors; alpha(2)-autoreceptors; myenteric plexus; noradrenaline; guinea-pig;

D O I：

10.1016/S0304-3940(97)13344-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We have studied the effect of [D-Ala(2)-N-Me-Phe(4),Gly-ol(5)]-enkephalin (DAMGO) opioid mu-receptor agonist) and ICI-204,448 (kappa-receptor agonist) on endogenous noradrenaline release in the guinea-pig isolated distal colon. DAMGO enhances noradrenaline overflow and this effect is antagonized by naloxone (PIC50=10.27) and nor-binaltorphimine (pIC(50)=7.97), and concentration-dependently turned into inhibition by yohimbine. ICI-204,448 inhibits noradrenaline overflow and is antagonized by naloxone(pIC(50)=9.38) and nor-binaltorphimine (pIC(50)=10.48), but is not affected by yohimbine. Evidence is thus' given that mu and kappa-opioid receptors modulate noradrenaline release in the guinea-pig colon. Modifications by yohimbine of the effect of DAMGO indicate the existence of a functional relationship between mu-receptors and alpha(2)-autoreceptors in this model. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：75 / 78

页数：4

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