Peak bone mass after exposure to antenatal betamethasone and prematurity: Follow-up of a randomized controlled trial

被引:46
作者
Dalziel, Stuart R.
Fenwick, Sheryl
Cundy, Tim
Parag, Varsha
Beck, Thomas J.
Rodgers, Anthony
Harding, Jane E.
机构
[1] Univ Auckland, Dept Neonatol, Liggins Inst, Auckland 1, New Zealand
[2] Univ Auckland, Clin Trials Res Unit, Auckland 1, New Zealand
[3] Univ Auckland, Dept Med, Auckland 1, New Zealand
[4] Johns Hopkins Univ Hosp, Baltimore, MD 21287 USA
关键词
clinical trials; epidemiology; corticosteroids; bone densitometry; clinical/pediatrics;
D O I
10.1359/JBMR.060516
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Small birth size is associated with reduced adult bone mass. We determined if antenatal betamethasone exposure, birth weight, or prematurity affects peak bone mass in 174 adults. Antenatal betamethasone exposure did not. Lower birth weight and prematurity predicted reduced adult height. Slower fetal growth rather than prematurity predicted lower bone mass, but this lower bone mass was appropriate for reduced adult height.
引用
收藏
页码:1175 / 1186
页数:12
相关论文
共 49 条
[1]  
[Anonymous], 1994, NIH Consens Statement, V12, P1
[2]  
[Anonymous], 2000, CDC GROWTH CHARTS US
[3]   Association of birth weight with osteoporosis and osteoarthritis in adult twins [J].
Antoniades, L ;
MacGregor, AJ ;
Andrew, T ;
Spector, TD .
RHEUMATOLOGY, 2003, 42 (06) :791-796
[4]   Early life influences on serum 1,25 (OH)2 vitamin D [J].
Arden, NK ;
Syddall, HE ;
Javaid, MK ;
Dennison, EM ;
Swaminathan, R ;
Fall, C ;
Cooper, C .
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY, 2005, 19 (01) :36-42
[5]  
Barker DJ., 1998, Mothers, babies, and health in later life, V2
[6]   PREDICTING FEMORAL-NECK STRENGTH FROM BONE-MINERAL DATA - A STRUCTURAL APPROACH [J].
BECK, TJ ;
RUFF, CB ;
WARDEN, KE ;
SCOTT, WW ;
RAO, GU .
INVESTIGATIVE RADIOLOGY, 1990, 25 (01) :6-18
[7]   Structural adaptation to changing skeletal load in the progression toward hip fragility: The study of osteoporotic fractures [J].
Beck, TJ ;
Oreskovic, TL ;
Stone, KL ;
Ruff, CB ;
Ensrud, K ;
Nevitt, MC ;
Genant, HK ;
Cummings, SR .
JOURNAL OF BONE AND MINERAL RESEARCH, 2001, 16 (06) :1108-1119
[8]   Structural trends in the aging femoral neck and proximal shaft: Analysis of the Third National Health and Nutrition Examination Survey dual-energy X-ray absorptiometry data [J].
Beck, TJ ;
Looker, AC ;
Ruff, CB ;
Sievanen, H ;
Wahner, HW .
JOURNAL OF BONE AND MINERAL RESEARCH, 2000, 15 (12) :2297-2304
[9]   GLUCOCORTICOID EXPOSURE INUTERO - NEW MODEL FOR ADULT HYPERTENSION [J].
BENEDIKTSSON, R ;
LINDSAY, RS ;
NOBLE, J ;
SECKL, JR ;
EDWARDS, CRW .
LANCET, 1993, 341 (8841) :339-341
[10]   Body composition in infants with chronic lung disease after treatment with dexamethasone [J].
Bolt, RJ ;
van Weissenbruch, MM ;
Roos, JC ;
Delemaare-van de Waal, HA ;
Cranendonk, A ;
Lafeber, HN .
ACTA PAEDIATRICA, 2002, 91 (07) :815-821