Antineoplastic agents .1. Three Spirostanol glycosides from rhizomes of Dioscorea collettii var hypoglauca

被引：127

作者：

Hu, K

Dong, AJ

Yao, XS

Kobayashi, H

Iwasaki, S

机构：

[1] SHENYANG PHARMACEUT UNIV,DEPT PHYTOCHEM,SHENYANG 110015,PEOPLES R CHINA

[2] INST NE GEN FARMACEUT FACTORY,SHENYANG 110026,LIAONING,PEOPLES R CHINA

[3] UNIV TOKYO,INST MOL & CELLULAR BIOSCI,BUNKYO KU,TOKYO 113,JAPAN

来源：

PLANTA MEDICA | 1996年 / 62卷 / 06期

关键词：

D O I：

10.1055/s-2006-957978

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

By activity-guided fractionation, three known steroidal saponins, prosapogenin A of dioscin, dioscin and gracillin, were isolated from the total saponin fraction of Dioscorea collettii var. hypoglauca as active compounds causing morphological abnormality of Pyricularia oryzae mycelia. The compounds also exhibited cytotoxic activity against the cancer cell line K562 in vitro. The structures of the compounds were elucidated on the basis of chemical evidence and IR, FAB-MS, H-1-NMR, C-13-NMR, and two-dimensional NMR (2D-NMR) analysis.

引用

页码：573 / 575

页数：3

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