Autophagy is required for extension of yeast chronological life span by rapamycin

被引：146

作者：

Alvers, Ashley L. ^{[2
]}

Wood, Michael S. ^{[1
]}

Hu, Doreen ^{[1
]}

Kaywell, Amelia C. ^{[1
]}

Dunn, William A., Jr. ^{[1
]}

Aris, John P. ^{[1
]}

机构：

[1] Univ Florida, Dept Anat & Cell Biol, Hlth Sci Ctr, Gainesville, FL 32610 USA

[2] Duke Univ, Med Ctr, Dept Cell Biol, Durham, NC 27710 USA

来源：

AUTOPHAGY | 2009年 / 5卷 / 06期

关键词：

autophagy; aging; chronological life span; rapamycin; Saccharomyces cerevisiae; TOR; RECRUITMENT; GROWTH;

D O I：

10.4161/auto.8824

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Rapamycin is an antibiotic that stimulates autophagy in a wide variety of eukaryotes, including the budding yeast Saccharomyces cerevisiae. Low concentrations of rapamycin extend yeast chronological life span (CLS). We have recently shown that autophagy is required for chronological longevity in yeast, which is attributable in part to a role for autophagy in amino acid homeostasis. We report herein that low concentrations of rapamycin stimulate macroautophagy during chronological aging and extend CLS.

引用

页码：847 / 849

页数：3

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