A new form of cerebellar long-term potentiation is postsynaptic and depends on nitric oxide but not cAMP

被引：227

作者：

Lev-Ram, V

Wong, ST

Storm, DR

Tsien, RY ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Pharmacol, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Howard Hughes Med Inst, La Jolla, CA 92093 USA

[3] Univ Washington, Sch Med, Dept Pharmacol, Seattle, WA 98195 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2002年 / 99卷 / 12期

关键词：

D O I：

10.1073/pnas.122206399

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Long-term depression (LTD) at cerebellar parallel fiber (PF)-Purkinje cell synapses must be balanced by long-term potentiation (LTP) to prevent saturation and allow reversal of motor learning. The only previously analyzed form of cerebellar LTP is induced by 4-8 Hz PF stimulation and requires cAMP but not nitric oxide. It is a poor candidate to reverse LTD because it is presynaptically expressed whereas LTD is postsynaptic. We now characterize a new form of LTP induced by 1 Hz PF stimulation for at least 300 s. This LTIP is postsynaptically expressed, enhanced by chelating postsynaptic Ca2+, and depends on nitric oxide but not cAMP or cGMP, making it a plausible anti-Hebbian counterpart to Hebbian LTD.

引用

页码：8389 / 8393

页数：5

共 41 条

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