Anti-cytokine therapies in T1D: Concepts and strategies

被引：60

作者：

Nepom, Gerald T. ^{[1
]}

Ehlers, Mario ^{[2
]}

Mandrup-Poulsen, Thomas ^{[3
,4
]}

机构：

[1] Benaroya Res Inst, Seattle, WA 98101 USA

[2] Immune Tolerance Network, San Francisco, CA 94107 USA

[3] Univ Copenhagen, DK-2200 Copenhagen N, Denmark

[4] Karolinska Inst, S-17176 Stockholm, Sweden

来源：

CLINICAL IMMUNOLOGY | 2013年 / 149卷 / 03期

关键词：

Immunotherapy; Autoimmunity; Regulatory T cells; Anti-inflammatory; INTERLEUKIN-12/23; MONOCLONAL-ANTIBODY; NONOBESE DIABETIC MICE; T-CELLS; DOUBLE-BLIND; TH17; CELLS; ENDOGENOUS INTERLEUKIN-12; NOD MICE; USTEKINUMAB; PSORIASIS; ONSET;

D O I：

10.1016/j.clim.2013.02.003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Therapeutic targeting of proinflammatory cytokines is clinically beneficial in several autoimmune disorders. Several of these cytokines are directly implicated in the pathogenesis of type 1 diabetes, suggesting opportunities for design of clinical trials in type 1 diabetes that incorporate selective cytokine blockade as a component of preventative or interventional immunotherapy. The rationale and status of inhibitory therapy directed against IL-1, TNF, IL-12, IL-23, and IL-6 are discussed, towards a goal of using cytokine inhibition as a therapeutic platform to establish an in vivo milieu suitable for modulating the immune response in T1D. (C) 2013 Elsevier Inc. All rights reserved.

引用

收藏

页码：279 / 285

页数：7

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