Galanin in the brain: chemoarchitectonics and brain cartography - a historical review

被引：54

作者：

Jacobowitz, DM ^{[1
]}

Kresse, A

Skofitsch, G

机构：

[1] NIMH, Clin Sci Lab, NIH, Bethesda, MD 20892 USA

[2] Uniformed Serv Univ Hlth Sci, Dept Anat Physiol & Genet, Bethesda, MD 20814 USA

[3] Graz Univ, Dept Zool, Sect Wildlife Res & Parasitol, A-1080 Graz, Austria

来源：

PEPTIDES | 2004年 / 25卷 / 03期

关键词：

galanin; brain; histochemistry; brain cartography; chemoarchitectonics; brain maps; Neuropeptides; in situ hybridization histochemistry; brain atlas; colocalization; gene expression;

D O I：

10.1016/j.peptides.2004.02.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We present a review of galanin in the brain from a historical perspective of the development of "chemoarchitectonics" and "brain cartography" accomplished in the Histopharmacology Section at the National Institutes of Health. It was the mapping of potential brain neuroregulators that served as a springboard of ideas from which behavioral studies emanate. The integration of the known localization of neurotransmitter/neuromodulatory nerves ("chemoarchitectonic maps") and receptor binding sites with biochemical data derived from brain micropunches Coupled with behavioral analysis at the level of discrete brain allows one to define the anatomical circuits which support behavioral changes and which ultimately will improve our understanding of mental disorders. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：433 / 464

页数：32

共 101 条

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