Potential usefulness of bovine lactoferrin for adjunctive immunotherapy for mucosal Candida infections

被引:12
作者
Yamaguchi, H [1 ]
Abe, S
Takakura, N
机构
[1] Teikyo Univ, Inst Med Mycol, Tokyo 1920395, Japan
[2] Morinaga Milk Ind Co Ltd, Nutr Sci Lab, Kanagawa 2288583, Japan
关键词
anti-Candida activity; bovine lactoferrin; immunotherapy; mucosal candidiasis;
D O I
10.1023/B:BIOM.0000027699.19078.a7
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Immunosuppressed children and adults have a higher prevalence of oropharyngeal candidiasis. In this patient population, anti-fungal therapy of this condition is often ineffective, and new approaches to treatment are needed. The use of bovine lactoferrin is considered a promising option in treating oropharyngeal candidiasis. Here we review the results of in vitro and in vivo studies that have examined the antimicrobial characteristics of bovine lactoferrin as an adjunctive therapy for oropharyngeal candidiasis.
引用
收藏
页码:245 / 248
页数:4
相关论文
共 25 条
[1]  
Abe S, 2000, INT CONGR SER, V1195, P195
[2]   Refractory mucosal candidiasis in patients with human immunodeficiency virus infection [J].
Fichtenbaum, CJ ;
Powderly, WG .
CLINICAL INFECTIOUS DISEASES, 1998, 26 (03) :556-565
[3]  
GAHR M, 1991, J LEUKOCYTE BIOL, V49, P1587
[4]   Synergistic fungistatic effects of lactoferrin in combination with antifungal drugs against clinical Candida isolates [J].
Kuipers, ME ;
de Vries, HG ;
Eikelboom, MC ;
Meijer, DKF ;
Swart, PJ .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (11) :2635-2641
[5]   Complete response of severe, refractory oral candidiasis to mouthwash containing lactoferrin and lysozyme [J].
Masci, JR .
AIDS, 2000, 14 (15) :2403-2404
[6]   FACTORS ASSOCIATED WITH INCREASED FREQUENCY OF HIV-RELATED ORAL CANDIDIASIS [J].
MCCARTHY, GM ;
MACKIE, ID ;
KOVAL, J ;
SANDHU, HS ;
DALEY, TD .
JOURNAL OF ORAL PATHOLOGY & MEDICINE, 1991, 20 (07) :332-336
[7]   Bovine lactoferrin stimulates the phagocytic activity of human neutrophils: Identification of its active domain [J].
Miyauchi, H ;
Hashimoto, S ;
Nakajima, M ;
Shinoda, I ;
Fukuwatari, Y ;
Hayasawa, H .
CELLULAR IMMUNOLOGY, 1998, 187 (01) :34-37
[8]  
Okutomi T, 1997, FEMS IMMUNOL MED MIC, V18, P105, DOI 10.1111/j.1574-695X.1997.tb01034.x
[9]  
OSEAS R, 1981, BLOOD, V57, P939
[10]  
SAMONIS G, 1990, REV INFECT DIS, V12, pS369