Recognition of regulatory sites by genomic comparison

被引：38

作者：

Gelfand, MS ^{[1
]}

机构：

[1] State Sci Ctr Biotechnol NIIGenet, Moscow 113545, Russia

来源：

RESEARCH IN MICROBIOLOGY | 1999年 / 150卷 / 9-10期

关键词：

transcription; regulation; operator; repressor; activator; computer analysis; complete genome;

D O I：

10.1016/S0923-2508(99)00117-5

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Availability of complete bacterial genomes opens the way to the comparative approach to the recognition of transcription regulatory sites. Assumption of regulon conservation in conjunction with profile analysis provides two lines of independent evidence making it possible to make highly specific predictions. Recently this approach was used to analyze several regulons in eubacteria and archaebacteria. The present review covers recent advances in the comparative analysis of transcriptional regulation in prokaryotes and phylogenetic fingerprinting techniques in eukaryotes, and describes the emerging patterns of the evolution of regulatory systems. (C) 1999 Editions scientifiques et medicales Elsevier SAS.

引用

页码：755 / 771

页数：17

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