Eighteen new polymorphic markers in the multiple endocrine neoplasia type 1 (MEN1) region

被引：52

作者：

Manickam, P

Guru, SC

Debelenko, LV

Agarwal, SK

Olufemi, SE

Weisemann, JM

Boguski, MS

Crabtree, JS

Wang, YP

Roe, BA

Lubensky, IA

Zhuang, ZP

Kester, MB

Burns, AL

Spiegel, AM

Marx, SJ

Liotta, LA

EmmertBuck, MR

Collins, FS

Chandrasekharappa, SC

机构：

[1] NATL HUMAN GENOME RES INST, LAB GENE TRANSFER, NIH, BETHESDA, MD 20892 USA

[2] NCI, PATHOL LAB, NIH, BETHESDA, MD 20892 USA

[3] NIDDKD, METAB DIS BRANCH, NIH, BETHESDA, MD 20892 USA

[4] UNIV OKLAHOMA, DEPT CHEM & BIOCHEM, NORMAN, OK 73019 USA

[5] NIH, NATL CTR BIOTECHNOL INFORMAT, NATL LIB MED, BETHESDA, MD 20894 USA

来源：

HUMAN GENETICS | 1997年 / 101卷 / 01期

关键词：

D O I：

10.1007/s004390050595

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder in which affected individuals develop tumors primarily in the parathyroids, anterior pituitary, endocrine pancreas, and duodenum. The locus fur MEN1 is tightly linked to the marker PYGM on chromosome 11q13, and linkage analysis has previously placed the MEN1 gene within a 2-Mb Interval flanked by markers D11S1883 and D11S449. Loss of heterozygosity (LOH) studies in MEN1 and sporadic tumors have helped narrow the location of the gene to a 600-kb interval between PYGM and D11S449. Eighteen new polymerase chain reaction (PCR)-based polymorphic markers were generated for the MEN1 region, with ten mapping to the PYGM-D11S449 interval. These new markers, along with 14 previously known polymorphic markers, were precisely mapped on a 2.8-Mb (D11S480-D11S913) high-density clone contig-based, physical map generated for the MEN1 region.

引用

页码：102 / 108

页数：7

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