DNA-functionalized nanotube membranes with single-base mismatch selectivity

被引：276

作者：

Kohli, P

Harrell, CC

Cao, ZH

Gasparac, R

Tan, WH

Martin, CR ^{[1
]}

机构：

[1] Univ Florida, Dept Chem, Gainesville, FL 32611 USA

[2] Univ Florida, Ctr Res Bionano Interface, Gainesville, FL 32611 USA

来源：

SCIENCE | 2004年 / 305卷 / 5686期

关键词：

D O I：

10.1126/science.1100024

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We describe synthetic membranes in which the molecular recognition chemistry used to accomplish selective permeation is DNA hybridization. These membranes contain template-synthesized gold nanotubes with inside diameters of 12 nanometers, and a "transporter" DNA-hairpin molecule is attached to the inside walls of these nanotubes. These DNA-functionalized nanotube membranes selectively recognize and transport the DNA strand that is complementary to the transporter strand, relative to DNA strands that are not complementary to the transporter. Under optimal conditions, single-base mismatch transport selectivity can be obtained.

引用

页码：984 / 986

页数：3

共 15 条

[1] Structure and mechanism of the lactose permease of Escherichia coli [J].