Molecular Identification of Aspergillus Species Collected for the Transplant-Associated Infection Surveillance Network

被引：251

作者：

Balajee, S. Arunmozhi ^{[1
]}

Kano, Rui ^{[1
]}

Baddley, John W. ^{[2
,4
]}

Moser, Stephen A. ^{[3
]}

Marr, Kieren A. ^{[5
,6
]}

Alexander, Barbara D. ^{[7
]}

Andes, David ^{[8
]}

Kontoyiannis, Dimitrios P. ^{[9
]}

Perrone, Giancarlo ^{[10
]}

Peterson, Stephen ^{[11
]}

Brandt, Mary E. ^{[1
]}

Pappas, Peter G. ^{[2
]}

Chiller, Tom ^{[1
]}

机构：

[1] Ctr Dis Control & Prevent, Mycot Dis Branch, Atlanta, GA 30333 USA

[2] Univ Alabama Birmingham, Dept Med, Birmingham, AL 35294 USA

[3] Univ Alabama Birmingham, Dept Pathol, Birmingham, AL 35294 USA

[4] Birmingham Vet Affairs Med Ctr, Dept Med, Birmingham, AL USA

[5] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA

[6] Johns Hopkins Univ, Baltimore, MD USA

[7] Duke Univ, Durham, NC USA

[8] Univ Wisconsin, Madison, WI USA

[9] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[10] CNR, Inst Sci Food Prod, Bari, Italy

[11] USDA, Natl Ctr Agr Utilizat Res, Peoria, IL USA

来源：

JOURNAL OF CLINICAL MICROBIOLOGY | 2009年 / 47卷 / 10期

关键词：

HEMATOPOIETIC STEM-CELL; INVASIVE ASPERGILLOSIS; SP NOV; FUMIGATUS; LENTULUS; PCR;

D O I：

10.1128/JCM.01070-09

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A large aggregate collection of clinical isolates of aspergilli (n = 218) from transplant patients with proven or probable invasive aspergillosis was available from the Transplant-Associated Infection Surveillance Network, a 6-year prospective surveillance study. To determine the Aspergillus species distribution in this collection, isolates were subjected to comparative sequence analyses by use of the internal transcribed spacer and beta-tubulin regions. Aspergillus fumigatus was the predominant species recovered, followed by A. flavus and A. niger. Several newly described species were identified, including A. lentulus and A. calidoustus; both species had high in vitro MICs to multiple antifungal drugs. Aspergillus tubingensis, a member of the A. niger species complex, is described from clinical specimens; all A. tubingensis isolates had low in vitro MICs to antifungal drugs.

引用

页码：3138 / 3141

页数：4

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