Influence of isoflurane concentration and hypoxia on functional magnetic resonance imaging for the detection of bicuculline-induced neuronal activation

被引：6

作者：

Abo, M

Suzuki, M

Senoo, A

Miyano, S

Yamauchi, H

Yonemoto, K

Watanabe, S

Edström, L

机构：

[1] Jikei Univ, Sch Med, Dept Rehabil Med, Minato Ku, Tokyo 1058461, Japan

[2] Jikei Univ, Sch Med, Dept Neurol, Tokyo 1058461, Japan

[3] Tokyo Metropolitan Univ Hlth Sci, Tokyo, Japan

[4] Karolinska Hosp, Dept Clin Neurosci, S-10401 Stockholm, Sweden

来源：

NEUROSIGNALS | 2004年 / 13卷 / 03期

关键词：

functional MRI; cerebral blood volume; intravascular contrast agent; bicuculline; pharmacological stimulation; hypoxia; epileptic seizures;

D O I：

10.1159/000076568

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Our present study shows that transient changes in relative cerebral blood volume (rCBV) induced by stimulation with bicuculline under six different conditions of anesthesia can be detected with high spatial resolution functional magnetic resonance imaging (fMRI). Bicuculline was administered at a low dose to induce neural activation, and no seizure activity was noted. Of the six conditions, the maximal reaction to bicuculline was observed under 1.5% isoflurane in 60% nitrogen and 40% oxygen. Our results imply that the rCBV changes under this level of isoflurane anesthesia with body temperature maintained at 37.5degreesC are probably suitable for further fMRI studies. Copyright (C) 2004 S. Karger AG, Basel.

引用

页码：144 / 149

页数：6

共 22 条

[1] Effects of small concentrations of volatile anesthetics on action potential firing of neocortical neurons in vitro [J].