Nogo and axon regeneration

被引：509

作者：

Schwab, ME

机构：

[1] Univ Zurich, Brain Res Inst, CH-8057 Zurich, Switzerland

[2] Swiss Fed Inst Technol, Dept Biol, CH-8057 Zurich, Switzerland

来源：

CURRENT OPINION IN NEUROBIOLOGY | 2004年 / 14卷 / 01期

基金：

瑞士国家科学基金会;

关键词：

D O I：

10.1016/j.conb.2004.01.004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Nogo-A is one of several neurite growth inhibitory components present in oligodendrocytes and CNS myelin membranes. Nogo has a crucial role in restricting axonal regeneration and compensatory fibre growth in the injured adult mammalian CNS. Recent studies have shown that in vivo applications of Nogo neutralizing antibodies, peptides blocking the Nogo receptor subunit NgR, or blockers of the postreceptor components Rho-A and ROCK induce long-distance axonal regeneration and compensatory sprouting, accompanied by an impressive enhancement of functional recovery, in the rat and mouse spinal cord.

引用

收藏

页码：118 / 124

页数：7

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