Pharmacological manipulation of granulocyte apoptosis: potential therapeutic targets

被引：145

作者：

Ward, C ^{[1
]}

Dransfield, I ^{[1
]}

Chilvers, ER ^{[1
]}

Haslett, C ^{[1
]}

Rossi, AG ^{[1
]}

机构：

[1] Univ Cambridge, Addenbrookes Hosp, Sch Med, Dept Med,Resp Med Div, Cambridge CB2 2QQ, England

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 1999年 / 20卷 / 12期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0165-6147(99)01391-7

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Resolution of inflammation involves the clearance of excess or effete inflammatory cells by a process of physiological programmed cell death (apoptosis) and the subsequent recognition and removal of apoptotic cells by phagocytes. The therapeutic induction of apoptosis for the resolution of chronic inflammation and the general pharmacology of apoptosis have become subjects of increasing interest. In this article, some of the unique and important differences in the control of apoptosis of various inflammatory cells (particularly neutrophil and eosinophil granulocytes) are highlighted. It is suggested that apoptosis can be specifically regulated pharmacologically and could be exploited to develop new drug therapies.

引用

页码：503 / 509

页数：7

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