Proteomics for the discovery of biomarkers and diagnosis of periodontitis: a critical review

被引：27

作者：

Guzman, Yannis A. ^{[1
]}

Sakellari, Dimitra ^{[2
]}

Arsenakis, Minas ^{[3
]}

Floudas, Christodoulos A. ^{[1
]}

机构：

[1] Princeton Univ, Dept Chem & Biol Engn, Princeton, NJ 08544 USA

[2] Aristotle Univ Thessaloniki, Dept Prevent Dent Periodontol & Implant Biol, GR-54006 Thessaloniki, Greece

[3] Aristotle Univ Thessaloniki, Sch Biol, Dept Genet Dev & Mol Biol, GR-54006 Thessaloniki, Greece

来源：

EXPERT REVIEW OF PROTEOMICS | 2014年 / 11卷 / 01期

基金：

美国国家科学基金会;

关键词：

2D gel electrophoresis; aggressive periodontitis; biomarkers; chronic periodontitis; gingivitis; gingival crevicular fluid; shotgun proteomics; whole saliva; GINGIVAL CREVICULAR FLUID; ACQUIRED ENAMEL PELLICLE; TANDEM MASS-SPECTROMETRY; C-REACTIVE PROTEIN; SALIVARY PROTEOME; PORPHYROMONAS-GINGIVALIS; HEALTH-STATUS; IDENTIFICATION; EXPRESSION; DISEASE;

D O I：

10.1586/14789450.2014.864953

中图分类号：

Q5 [生物化学];

学科分类号：

070307 [化学生物学];

摘要：

Periodontitis is a common chronic and destructive disease whose pathogenetic mechanisms remain unclear. Due to their sensitivity and global scale, proteomics studies offer the opportunity to uncover critical host and pathogen activity indicators and can elucidate clinically applicable biomarkers for improved diagnosis and treatment of the disease. This review summarizes the literature of proteomics studies on periodontitis and comprehensively discusses commonly found candidate biomarkers. Key considerations in the design of an experimental proteomics platform are also outlined. The applicability of protein biomarkers across the progression of periodontitis and unexplored areas of research are highlighted.

引用

页码：31 / 41

页数：11

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