Mitochondrial Dynamics: Coupling Mitochondrial Fitness with Healthy Aging

被引：278

作者：

Sebastian, David ^{[1
,2
,3
]}

Palacin, Manuel ^{[1
,2
,4
]}

Zorzano, Antonio ^{[1
,2
,3
]}

机构：

[1] Inst Res Biomedicine IRB Barcelona, Barcelona Inst Sci & Technol, Barcelona, Spain

[2] Univ Barcelona, Fac Biol, Dept Bioqulm Biomed Mol, Barcelona, Spain

[3] Inst Salud Carlos III, Cent Investigac Biomed Red Diabet Enfermedades, Madrid, Spain

[4] Inst Salud Carlos III, Centro Investigac Blomed Red Enfermedades Raras C, Madrid, Spain

来源：

TRENDS IN MOLECULAR MEDICINE | 2017年 / 23卷 / 03期

关键词：

DOMINANT OPTIC ATROPHY; LIFE-SPAN EXTENSION; MITOFUSIN; MAMMALIAN-CELLS; ENDOPLASMIC-RETICULUM; SKELETAL-MUSCLE; PROTEIN DRP1; EMBRYONIC-DEVELOPMENT; LINKS MITOCHONDRIAL; PEROXISOMAL FISSION;

D O I：

10.1016/j.molmed.2017.01.003

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Aging is associated with a decline in mitochondrial function and the accumulation of abnormal mitochondria. However, the precise mechanisms by which aging promotes these mitochondria alterations and the role of the latter in aging are still not fully understood. Mitochondria dynamics is a key process regulating mitochondria! function and quality. Altered expression of some mitochondria dynamics proteins has been recently associated with aging and with age-related alterations in yeast, Caenorhabditis elegans, mice, and humans. Here, we review the link between alterations in mitochondria dynamics, aging, and age-related impairment. We propose that the dysregulation of mitochondrial dynamics leads to age-induced accumulation of unhealthy mitochondria and contributes to alterations linked to aging, such as diabetes and neurodegeneration.

引用

收藏

页码：201 / 215

页数：15

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