LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1

被引：154

作者：

Yang, XL

Yu, KP

Hao, YW

Li, DM

Stewart, R

Insogna, KL

Xu, T

机构：

[1] Yale Univ, Sch Med, Boyer Ctr Mol Med, Howard Hughes Med Inst, New Haven, CT 06536 USA

[2] Yale Univ, Sch Med, Boyer Ctr Mol Med, Dept Genet, New Haven, CT 06536 USA

[3] Yale Univ, Sch Med, Boyer Ctr Mol Med, Dept Med, New Haven, CT 06536 USA

来源：

NATURE CELL BIOLOGY | 2004年 / 6卷 / 07期

关键词：

D O I：

10.1038/ncb1140

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

LATS (large tumour suppressor) is a family of conserved tumour suppressors identified in Drosophila and mammals. Here we show that human LATS1 binds to LIMK1 in vitro and in vivo and colocalizes with LIMK1 at the actomyosin contractile ring during cytokinesis. LATS1 inhibits both the phosphorylation of cofilin by LIMK1 and LIMK1-induced cytokinesis defects. Inactivation of LATS1 by antibody microinjection or RNA-mediated interference in cells, or gene knockout in mice, abrogates cytokinesis and increases the percentage of multinucleate cells. Our findings indicate that LATS1 is a novel cytoskeleton regulator that affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1.

引用

页码：609 / 617

页数：9

共 48 条

[1] Mitosis-specific activation of LIM motif-containing protein kinase and roles of cofilin phosphorylation and dephosphorylation in mitosis [J].