Potent skin cancer chemopreventing activity of some novel semi-synthetic cembranoids from marine sources

被引：19

作者：

Fahmy, Hesham

Zjawiony, Jordan K.

Konoshima, Takao

Tokuda, Harukuni

Khan, Shabana

Khalifa, Sherief

机构：

[1] S Dakota State Univ, Dept Pharmaceut Sci, Brookings, SD 57007 USA

[2] Univ Mississippi, Sch Pharm, Res Inst Pharmaceut Sci, Dept Pharmacognosy, University, MS 38677 USA

[3] Univ Mississippi, Sch Pharm, Res Inst Pharmaceut Sci, Nat Ctr Nat Prod Res, University, MS 38677 USA

[4] Kyoto Pharmaceut Univ, Yamashina Ku, Kyoto 6078414, Japan

[5] Kyoto Prefectural Univ Med, Dept Mol Biochem, Kamigyo Ku, Kyoto 6020841, Japan

[6] Univ Mississippi, Res Inst Pharmaceut Sci, Natl Ctr Nat Prod Res, University, MS 38677 USA

[7] Suez Canal Univ, Fac Pharm, Dept Pharmacognosy, Ismailia, Egypt

来源：

MARINE DRUGS | 2006年 / 4卷 / 02期

关键词：

cancer chemoprevention; skin cancer; cembranoids; sarcophine; Sarcophyton glaucum;

D O I：

10.3390/md402028

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

In the course of our continuing research in development and evaluation of novel skin cancer chemopreventive agents from marine sources, five semi-synthetic cembranoids derived from the marine natural product sarcophine, isolated from the soft coral Sarcophyton glaucum, were synthesized and shown to exhibit a remarkable chemopreventive activity in the in-vitro Epstein Barr Virus Early Antigen (EBV-EA) activation assay. These compounds were assayed in vivo using the two-stage carcinogenesis test of mouse skin tumors induced by 7,12-dimethylbenz[a] anthracene (DMBA) as an initiator, and 12-O-tetradecanoylphorbol-13-acetate (TPA) as a promoter by topical administration. They showed potent inhibition of both percentage incidence of skin tumor as well as the multiplicity of skin tumors per mouse compared to untreated controls.

引用

页码：28 / 36

页数：9

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