Deficient intracortical inhibition in drug-naive children with attention-deficit hyperactivity disorder is enhanced by methylphenidate

被引：141

作者：

Moll, GH ^{[1
]}

Heinrich, H ^{[1
]}

Trott, GE ^{[1
]}

Wirth, S ^{[1
]}

Rothenberger, A ^{[1
]}

机构：

[1] Univ Gottingen, D-37075 Gottingen, Germany

来源：

NEUROSCIENCE LETTERS | 2000年 / 284卷 / 1-2期

关键词：

motor system excitability; attention-deficit hyperactivity disorder; methylphenidate; transcranial magnetic stimulation; children;

D O I：

10.1016/S0304-3940(00)00980-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In children with attention-deficit hyperactivity disorder (ADHD), motoric hyperactivity is one of the striking abnormalities. Because this symptom might be due to an insufficient motor control, motor system excitability in 18 drug-naive ADHD-children aged 8-12 years was compared to 18 age-matched healthy children using the technique of transcranial magnetic stimulation (TMS). Whereas motor thresholds, cortical silent period, and intracortical facilitation did not differ between the two groups, ADHD-children had significantly reduced intracortical inhibition compared to healthy controls. In all ADHD-children, a second TMS could be started after their first intake of 10 mg methylphenidate. Under this medication, a significant enhancement in intracortical inhibition could be stated. This study provides the first evidence for inhibitory deficits within the motor cortex in ADHD-children and for an enhancement of inhibitory mechanisms in this brain region by methylphenidate. (C) 2000 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：121 / 125

页数：5

共 25 条

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