Structure and function of poly(A) binding proteins

被引：265

作者：

Kühn, U ^{[1
]}

Wahle, E ^{[1
]}

机构：

[1] Univ Halle Wittenberg, Inst Biochem, D-06120 Halle An Der Saale, Germany

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 2004年 / 1678卷 / 2-3期

关键词：

mRNA turnover; 3 ' end processing; poly(A) binding protein;

D O I：

10.1016/j.bbaexp.2004.03.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Poly (A) tails are found at the 3' ends of almost all eukaryotic mRNAs. They are bound by two different poly (A) binding proteins, PABPC in the cytoplasm and PABPN1 in the nucleus. PABPC functions in the initiation of translation and in the regulation of mRNA decay. In both functions, an interaction with the m7G cap at the 5' end of the message plays an important role. PABPN1 is involved in the synthesis of poly (A) tails, increasing the processivity of poly (A) polymerase and contributing to defining the length of a newly synthesized poly (A) tail. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：67 / 84

页数：18

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