Antiviral activity of antimicrobial cationic peptides against Junin virus and herpes simplex virus

被引：174

作者：

Matanic, VCA ^{[1
]}

Castilla, V ^{[1
]}

机构：

[1] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Quim Biol, Virol Lab, Buenos Aires, DF, Argentina

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2004年 / 23卷 / 04期

关键词：

arenavirus; herpesvirus; antimicrobial peptides; antiviral activity;

D O I：

10.1016/j.ijantimicag.2003.07.022

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The in vitro antiviral activity of antimicrobial cationic peptides: cecropin A, melittin, magainin I and 11 and indolicidin against the arenavirus Junin virus QV), and herpes simplex virus type 1 (HSV-1) and 2 (HSV-2) was evaluated. Cecropin A effectively inhibited JV multiplication and failed to affect HSV replication whereas melittin impeded the multiplication of JV and HSV, but was highly toxic for the host cell. Magainins I and II exhibited inhibitory action toward HSV-1 and HSV-2 but were inactive against JV. Only indolicidin showed a direct inactivation effect on cell-free virus stocks. Besides its inhibitory effect on JV replication cecropin A also was active against the arenaviruses Tacaribe and Pichinde, mainly affecting late events of arenavirus multiplication cycle by preventing viral morphogenesis and egress from infected cells. (C) 2004 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.

引用

页码：382 / 389

页数：8

共 26 条

[1]

ABOUDY Y, 1994, INT J PEPT PROT RES, V43, P573

[2]

Andreu D, 1998, BIOPOLYMERS, V47, P415, DOI 10.1002/(SICI)1097-0282(1998)47:6<415::AID-BIP2>3.0.CO

[3]

2-D

[4] ROLE OF THE NA+,K+ PUMP IN HERPES-SIMPLEX TYPE-1-INDUCED CELL-FUSION - MELITTIN CAUSES SPECIFIC REVERSION OF SYNCYTIAL MUTANTS WITH THE SYN1 MUTATION TO SYN+ (WILD-TYPE) PHENOTYPE [J].

BAGHIAN, A ;

KOUSOULAS, KG .

VIROLOGY, 1993, 196 (02) :548-556

[5]

Buchmeier MJ, 2002, CURR TOP MICROBIOL, V262, P159

[6] ANTIGENIC RELATIONSHIPS BETWEEN ATTENUATED AND PATHOGENIC STRAINS OF JUNIN VIRUS [J].

CANDURRA, NA ;

DAMONTE, EB ;

COTO, CE .

JOURNAL OF MEDICAL VIROLOGY, 1989, 27 (02) :145-150

[7] Effect of inhibitors of the intracellular exocytic pathway on glycoprotein processing and maturation of Junin virus [J].

Candurra, NA ;

Damonte, EB .

ARCHIVES OF VIROLOGY, 1997, 142 (11) :2179-2193

[8] Involvement of vacuolar proton ATPase in Junin virus multiplication [J].

Castilla, V ;

Palermo, LM ;

Coto, CE .

ARCHIVES OF VIROLOGY, 2001, 146 (02) :251-263

[9]

COMPANS RW, 1993, ARENAVIRIDAE

[10] DIRECT INACTIVATION OF VIRUSES BY HUMAN GRANULOCYTE DEFENSINS [J].

DAHER, KA ;

SELSTED, ME ;

LEHRER, RI .

JOURNAL OF VIROLOGY, 1986, 60 (03) :1068-1074

← 1 2 3 →