Renal Clearable Ag Nanodots for in Vivo Computer Tomography Imaging and Photothermal Therapy

被引：92

作者：

Cui, Yanyan ^{[1
]}

Yang, Jian ^{[1
]}

Zhou, Qunfang ^{[2
]}

Liang, Ping ^{[2
]}

Wang, Yaling ^{[3
]}

Gao, Xueyun ^{[3
]}

Wang, Yongtian ^{[1
]}

机构：

[1] Beijing Inst Technol, Sch Optoelect, Beijing Engn Res Ctr Mixed Real & Adv Display, Beijing 100081, Peoples R China

[2] Chinese Peoples Liberat Army Gen Hosp, Dept Intervent Ultrasound, Beijing 100853, Peoples R China

[3] Chinese Acad Sci, Inst High Energy Phys, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100049, Peoples R China

来源：

ACS APPLIED MATERIALS & INTERFACES | 2017年 / 9卷 / 07期

基金：

中国国家自然科学基金; 北京市自然科学基金;

关键词：

silver nanodots; protein; X-ray CT imaging; photothermal therapy; renal clearable; TRIGGERED DRUG-DELIVERY; BOVINE SERUM-ALBUMIN; SILVER NANOPARTICLES; FACILE; BIOMINERALIZATION; SENSITIVITY; NANOSHEETS; CONTRAST; CLUSTERS;

D O I：

10.1021/acsami.6b16133

中图分类号：

TB3 [工程材料学];

学科分类号：

082905 [生物质能源与材料];

摘要：

Albumin-stabilized Ag nanodots (ANDs) are prepared by a one-step biomineralization method. The highly crystallized nanodots have ultrasmall sizes (approximately 5.8 nm) and robust X-ray attenuation (5.7313 HU per mM Ag). The unlabeled ANDs are directly excreted from the body via the urine after in-vivo X-ray computer tomography (CT) imaging application. ANDs could be used as CT imaging agents and effective photothermal therapy agents. Tumor growth inhibition reaches 90.2% after photothermal treatment with ANDs. ANDs are promising tools for in vivo CT imaging and clearable near-infrared-triggered theranostic agents.

引用

收藏

页码：5900 / 5906

页数：7

相关论文

共 39 条

[1]

Toggling Between Blue- and Red-Emitting Fluorescent Silver Nanoclusters [J].

Anand, Uttam ;

Ghosh, Subhadip ;

Mukherjee, Saptarshi .

JOURNAL OF PHYSICAL CHEMISTRY LETTERS, 2012, 3 (23) :3605-3609

[2]

Quantifying the Sensitivity of Multipolar (Dipolar, Quadrupolar, and Octapolar) Surface Plasmon Resonances in Silver Nanoparticles: The Effect of Size, Composition, and Surface Coating [J].

Bastus, Neus G. ;

Piella, Jordi ;

Puntes, Victor .

LANGMUIR, 2016, 32 (01) :290-300

[3]

Inorganic dendrimers: recent advances for catalysis, nanomaterials, and nanomedicine [J].

Caminade, Anne-Marie .

CHEMICAL SOCIETY REVIEWS, 2016, 45 (19) :5174-5186

[4]

Simple and Efficient Synthesis of Strongly Green Fluorescent Carbon Dots with Upconversion Property for Direct Cell Imaging [J].

Cui, Yanyan ;

Zhang, Chunfang ;

Sun, Limei ;

Hu, Zhongbo ;

Liu, Xiangfeng .

PARTICLE & PARTICLE SYSTEMS CHARACTERIZATION, 2015, 32 (05) :542-546

[5]

Direct synthesis of CdS nanodots embedded in bovine serum albumin without external sulfur source for cell imaging [J].

Cui, Yanyan ;

Zhang, Chunfang ;

Sun, Limei ;

Hu, Zhongbo ;

Liu, Xiangfeng .

RSC ADVANCES, 2015, 5 (13) :10014-10017

[6]

Serial Silver Clusters Biomineralized by One Peptide [J].

Cui, Yanyan ;

Wang, Yaling ;

Liu, Ru ;

Sun, Zhipeng ;

Wei, Yueteng ;

Zhao, Yuliang ;

Gao, Xueyun .

ACS NANO, 2011, 5 (11) :8684-8689

[7]

Improving the MR Imaging Sensitivity of Upconversion Nanoparticles by an Internal and External Incorporation of the Gd3+ Strategy for in Vivo Tumor-Targeted Imaging [J].

Du, Hongli ;

Yu, Jiani ;

Guo, Dongcai ;

Yang, Weitao ;

Wang, Jun ;

Zhang, Bingbo .

LANGMUIR, 2016, 32 (04) :1155-1165

[8]

Silver Nanoparticles as Potential Antibacterial Agents [J].

Franci, Gianluigi ;

Falanga, Annarita ;

Galdiero, Stefania ;

Palomba, Luciana ;

Rai, Mahendra ;

Morelli, Giancarlo ;

Galdiero, Massimiliano .

MOLECULES, 2015, 20 (05) :8856-8874

[9]

Protein Induces Layer-by-Layer Exfoliation of Transition Metal Dichalcogenides [J].

Guan, Guijian ;

Zhang, Shuangyuan ;

Liu, Shuhua ;

Cai, Yongqing ;

Low, Michelle ;

Teng, Choon Peng ;

Phang, In Yee ;

Cheng, Yuan ;

Duei, Koh Leng ;

Srinivasan, Bharathi Madurai ;

Zheng, Yuangang ;

Zhang, Yong-Wei ;

Han, Ming-Yong .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2015, 137 (19) :6152-6155

[10]

Fluorescent copper nanoparticles: recent advances in synthesis and applications for sensing metal ions [J].

Guo, Yongming ;

Cao, Fengpu ;

Lei, Xiaoling ;

Mang, Lianghong ;

Cheng, Shengjuan ;

Song, Jintong .

NANOSCALE, 2016, 8 (09) :4852-4863

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