Colloidal stability of Pluronic F68-coated PLGA nanoparticles:: A variety of stabilisation mechanisms

Poloxamers are a family of polypropylene oxide (PPO) and polyethylene oxide (PEO) tri-block copolymers that are usually employed in the micro- and nanoparticulate engineering for drug delivery systems. The aim of this work is to study the electrophoretic mobility (mu e) and colloidal stability of complexes formed by adsorbing a poloxamer (Pluronic F68) onto poly(D,L-lactic-co-glycolic acid) (PLGA) nanoparticles. A variety of stabilisation mechanisms have been observed for the Pluronic-coated PLGA nanoparticles, where DLVO interactions, solvent-polymer segment interactions and hydration forces play different roles as a function of the adsorbed amount of Pluronic. In addition, the mu e and stability data of these complexes have been compared to those obtained previously using a PLGA-Pluronic F68 blend formulation. As both the mu e and the stability data are identical between the two systems, a phase separation of both components in the PLGA-Pluronic blend formulation is suggested, being the PLGA located in the core of the particles and the Pluronic in an adsorbed shell. (c) 2006 Elsevier Inc. All rights reserved.