Histo-Blood Group Antigen Phenotype Determines Susceptibility to Genotype-Specific Rotavirus Infections and Impacts Measures of Rotavirus Vaccine Efficacy

被引：68

作者：

Lee, Benjamin ^{[1
]}

Dickson, Dorothy M. ^{[2
]}

deCamp, Allan C. ^{[3
]}

Colgate, E. Ross ^{[2
]}

Diehl, Sean A. ^{[2
]}

Uddin, Muhammad Ikhtear ^{[4
]}

Sharmin, Salma ^{[4
]}

Islam, Shahidul ^{[4
,8
]}

Bhuiyan, Taufiqur Rahman ^{[4
]}

Alam, Masud ^{[4
]}

Nayak, Uma ^{[5
,6
]}

Mychaleckyj, Josyf C. ^{[5
,6
]}

Taniuchi, Mami ^{[7
]}

Petri, William A., Jr. ^{[7
]}

Haque, Rashidul ^{[4
]}

Qadri, Firdausi ^{[4
]}

Kirkpatrick, Beth D. ^{[2
]}

机构：

[1] Univ Vermont, Larner Coll Med, Vaccine Testing Ctr, Dept Pediat, 89 Beaumont Ave,Given C219, Burlington, VT 05405 USA

[2] Univ Vermont, Larner Coll Med, Vaccine Testing Ctr, Dept Med, Burlington, VT 05405 USA

[3] Fred Hutchinson Canc Res Ctr, Vaccine & Infect Dis Div, 1124 Columbia St, Seattle, WA 98104 USA

[4] Int Ctr Diarrhoea Dis Res Bangladesh, Dhaka, Bangladesh

[5] Univ Virginia, Ctr Publ Hlth Genom, Charlottesville, VA USA

[6] Univ Virginia, Dept Publ Hlth Sci, Charlottesville, VA USA

[7] Univ Virginia, Div Infect Dis & Int Hlth, Charlottesville, VA USA

[8] Kanazawa Univ, Dept Vasc Physiol, Grad Sch Med, Kanazawa, Ishikawa, Japan

来源：

JOURNAL OF INFECTIOUS DISEASES | 2018年 / 217卷 / 09期

基金：

比尔及梅琳达.盖茨基金会; 美国国家卫生研究院;

关键词：

rotavirus; secretor; Lewis; vaccination; vaccine efficacy; SECRETOR STATUS; CHILDREN; GASTROENTERITIS; DIARRHEA; ASSOCIATION;

D O I：

10.1093/infdis/jiy054

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Background. Lewis and secretor histo-blood group antigens (HBGAs) have been associated with decreased susceptibility to P[8] genotype rotavirus (RV) infections. Efficacy of vaccines containing attenuated P[8] strains is decreased in low-income countries. Host phenotype might impact vaccine efficacy (VE) by altering susceptibility to vaccination or RV diarrhea (RVD). We performed a substudy in a monovalent RV vaccine (RV1) efficacy trial in Bangladesh to determine the impact of Lewis and secretor status on risk of RVD and VE. Methods. In infants randomized to receive RV1 or no RV1 at 10 and 17 weeks with 1 year of complete active diarrheal surveillance, we performed Lewis and secretor phenotyping and genotyped the infecting strain of each episode of RVD. Results. A vaccine containing P[8] RV protected secretors and nonsecretors similarly. However, unvaccinated nonsecretors had a reduced risk of RVD (relative risk, 0.53 [95% confidence interval, .36-.79]) mediated by complete protection from P[4] but not P[8] RVs. This effect reduced VE in nonsecretors to 31.7%, compared to 56.2% among secretors, and decreased VE for the overall cohort. Conclusions. Host HBGA status may impact VE estimates by altering susceptibility to RV in unvaccinated children; future trials should therefore account for HBGA status.

引用

页码：1399 / 1407

页数：9

共 29 条

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Children with the Le(a plus b-) Blood Group Have Increased Susceptibility to Diarrhea Caused by Enterotoxigenic Escherichia coli Expressing Colonization Factor I Group Fimbriae [J].