Xanthomatous hypophysitis: A novel entity of obscure etiology

被引：29

作者：

Deodhare, SS

Bilbao, JM

Kovacs, K

Horvath, E

Nomikos, P

Buchfelder, M

Reschke, K

Lehnert, H

机构：

[1] Univ Toronto, St Michaels Hosp, Dept Lab Med, Toronto, ON M5B 1W8, Canada

[2] Univ Erlangen Nurnberg, Dept Neurosurg, D-8520 Erlangen, Germany

[3] Univ Magdeburg, Dept Endocrinol, D-39106 Magdeburg, Germany

来源：

ENDOCRINE PATHOLOGY | 1999年 / 10卷 / 03期

关键词：

pituitary; hypophysitis; differential diagnosis; immunohistochemistry; electron microscopy;

D O I：

10.1007/BF02738885

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We report a case of xanthomatous hypophysitis, a recently described entity of obscure etiology affecting the pituitary gland, in a 43-yr-old woman. Histologically it is characterized by infiltration of the anterior pituitary by foamy histiocytes which are strongly immunoreactive for CD68 (histiocytic marker) and are immunonegative for S100 and CD1a. Electron microscopy revealed histiocytes with abundant cytoplasmic lipid droplets and membrane bound vacuoles. Fragments of intact anterior pituitary with preserved vascular and reticulin networks are seen. Xanthomatous hypophysitis resembles neoplasm on clinical and radiologic grounds.

引用

页码：237 / 241

页数：5

共 12 条

[1] PRIMARY INTRACRANIAL PLASMA-CELL GRANULOMA - CASE-REPORT [J].