Blue-Light Phase Shifts PER3 Gene Expression in Human Leukocytes

被引：24

作者：

Ackermann, Katrin ^{[1
]}

Sletten, Tracey L. ^{[1
]}

Revell, Victoria L. ^{[1
]}

Archer, Simon N. ^{[1
]}

Skene, Debra J. ^{[1
]}

机构：

[1] Univ Surrey, Fac Hlth & Med Sci, Ctr Chronobiol, Surrey GU2 7XH, England

来源：

CHRONOBIOLOGY INTERNATIONAL | 2009年 / 26卷 / 04期

关键词：

PERIOD3; Phase shift; Melatonin; Leukocytes; Blue light; BLOOD MONONUCLEAR-CELLS; SHORT-WAVELENGTH LIGHT; HUMAN CIRCADIAN SYSTEM; CLOCK GENES; MELATONIN SUPPRESSION; HIGH-SENSITIVITY; GANGLION-CELLS; RHYTHM; PATTERNS; MAMMALS;

D O I：

10.1080/07420520902929045

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The timing of clock gene expression in human leukocytes was investigated following a phase-advancing light stimulus to determine whether the response is wavelength- and/or age-dependent. PERIOD3 (PER3) clock gene expression in leukocytes and plasma melatonin were analyzed before and after monochromatic blue and green light exposure. Significant phase advances were observed in the peak timing of both PER3 expression and melatonin following blue but not green light. The amplitude of the PER3 rhythm at baseline was significantly reduced with age. However, age did not affect the response of the PER3 rhythm to light. (Author correspondence: d.skene@surrey.ac.uk).

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收藏

页码：769 / 779

页数：11

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