Soluble T-lymphocyte antigen-specific immunoproteins: A progress report

被引：1

作者：

Cone, RE ^{[1
]}

Georgiou, GM

Little, CH

机构：

[1] Univ Connecticut, Ctr Hlth, Dept Pathol, Farmington, CT 06030 USA

[2] Natl Aging Res Inst, Parkville, Vic 3050, Australia

来源：

EXPERIMENTAL BIOLOGY AND MEDICINE | 2002年 / 227卷 / 07期

关键词：

serum TABM; TGF beta; immunoregulation; infectious and immune-mediated disease;

D O I：

10.1177/153537020222700707

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

T-cell-derived proteins that bind nominal (non-MHC-associated) antigen specifically (TABM) express V and C region epitopes of the T-cell receptor (TCR) for antigen and have a significant similarity in amino acid sequence to TCR alpha-chain V and C region. The presence of these immunoproteins in human serum and a specific increase in serum TABM in infectious disease, chemical sensitivity, and food intolerance suggest that TABM may impact on pathogenesis through the modulation of cell-mediated immunity, the antigen-specific concentration and delivery of immunoregulatory cytokines such as TGF-beta and elastase, and the induction of the release of substance P by sensory neurons. In this Minireview update, we describe advances in the detection and quantitation of human TABM by monoclonal antibodies, and the association of increased human serum TABM titers in infectious disease, chemical sensitivity, and food intolerance. We suggest that the immunomodulatory mode of action of these immunoproteins may be the antigen-specific focusing of cytokines associated with TABM.

引用

页码：438 / 444

页数：7

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