Design, synthesis and cytotoxic studies on the simplified oxy analog of eleutherobin

被引：16

作者：

Chandrasekhar, S ^{[1
]}

Jagadeshwar, V

Narsihmulu, C

Sarangapani, M

Krishna, DR

Vidyasagar, J

Vijay, D

Sastry, GN

机构：

[1] Indian Inst Chem Technol, Organ Div 1, Hyderabad 500007, Andhra Pradesh, India

[2] Kakatiya Univ, Univ Coll Pharmaceut Sci, Canc & Aging Res Div, Warangal 506009, Andhra Pradesh, India

[3] Indian Inst Chem Technol, Mol Modelling Grp, Hyderabad 500007, Andhra Pradesh, India

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 14期

关键词：

D O I：

10.1016/j.bmcl.2004.05.017

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A straight forward entry into nine membered B ring of eleutherobin as oxy analog and its cyctotoxic properties on HBL cell lines is described. Molecular modeling studies were carried out to ascertain the binding of the model compound to the active site of beta-tubulin. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：3687 / 3689

页数：3

共 33 条

[1]

[Anonymous], 2014, MOL OP ENV MOE SOFTW

[2] Synthesis of key intermediates for a concise and convergent approach to the marine natural product eleutherobin [J].

Baron, A ;

Caprio, V ;

Mann, J .

TETRAHEDRON LETTERS, 1999, 40 (52) :9321-9324

[3] Synthetic transformations of eleutherobin reveal new features of its microtubule-stabilizing pharmacophore [J].

Britton, R ;

de Silva, ED ;

Bigg, CM ;

McHardy, LM ;

Roberge, M ;

Andersen, RJ .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (35) :8632-8633

[4] Studies on the stereoselective synthesis of the marine antitumor agent eleutherobin [J].

Carter, R ;

Hodgetts, K ;

McKenna, J ;

Magnus, P ;

Wren, S .

TETRAHEDRON, 2000, 56 (26) :4367-4382

[5] Effect of ligands and additives on the palladium-promoted carbonylative coupling of vinyl stannanes and electron-poor enol triflates [J].

Ceccarelli, S ;

Piarulli, U ;

Gennari, C .

JOURNAL OF ORGANIC CHEMISTRY, 2000, 65 (19) :6254-6256

[6] Synthetic studies on sarcodictyins and eleutherobin: Synthesis of fully functionalized cyclization precursors [J].

Ceccarelli, S ;

Piarulli, U ;

Gennari, C .

TETRAHEDRON LETTERS, 1999, 40 (01) :153-156

[7] A carbonylative cross-coupling strategy to the total synthesis of the sarcodictyins: preliminary studies and synthesis of a cyclization precursor [J].

Ceccarelli, SM ;

Piarulli, U ;

Telser, J ;

Gennari, C .

TETRAHEDRON LETTERS, 2001, 42 (42) :7421-7425

[8] Synthetic studies on the sarcodictyins: synthesis of fully functionalized cyclization precursors [J].

Ceccarelli, SM ;

Piarulli, U ;

Gennari, C .

TETRAHEDRON, 2001, 57 (40) :8531-8542

[9]

Chen XT, 1998, ANGEW CHEM INT EDIT, V37, P789, DOI 10.1002/(SICI)1521-3773(19980403)37:6<789::AID-ANIE789>3.0.CO

[10]

2-3

← 1 2 3 4 →