Reversing DNA damage with a directional bias

被引：8

作者：

Begley, TJ ^{[1
]}

Samson, LD

机构：

[1] SUNY Albany, Gen NYsis Ctr Excellence Canc Genom, Dept Biomed Sci, Rensselaer, NY 12144 USA

[2] MIT, Biol Engn Div, Cambridge, MA 02139 USA

[3] MIT, Environm Hlth Sci Ctr, Cambridge, MA 02139 USA

来源：

NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2004年 / 11卷 / 08期

关键词：

D O I：

10.1038/nsmb0804-688

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Structures of the human O-6-alkylguanine-DNA alkyltransferase bound to substrate together with biochemical analysis provide clues to substrate acquisition and recognition, as well as details of the methyl transfer reaction catalyzed by this direct DNA repair protein.

引用

页码：688 / 690

页数：3

共 9 条

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