The effect of leptin on the ventilatory response to hyperoxia

被引：16

作者：

Groeben, H

Meier, S

Brown, RH

O'Donnell, CP

Mitzner, W

Tankersley, CG

机构：

[1] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Anesthesiol & Crit Care Med, Baltimore, MD USA

[2] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Environm Hlth Sci, Div Physiol, Baltimore, MD USA

[3] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Med, Div Pulm Med, Baltimore, MD USA

来源：

EXPERIMENTAL LUNG RESEARCH | 2004年 / 30卷 / 07期

关键词：

mice; peripheral chemoreceptor; whole body plethysmography;

D O I：

10.1080/01902140490489144

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

Leptin-deficient mice show a blunted response to hypercapnia explained by central nervous system effects. The impact of leptin on peripheral chemoreceptor function is unclear. Therefore, 9 mutant (ob/ob) and 9 wild-type (+/+) mice were exposed to room air or 100% oxygen and respiratory rate (RR) and tidal volume (Vt) were measured. Subsequently, ob/ob mice received either leptin or vehicle and measurements were repeated. Compared to baseline, for+/+mice, RR decreased significantly by 9.4%+/-3.0% (means+/-SD), whereas Vt remained unchanged. Transition from normoxia to hyperoxia did not change RR and Vt in untreated ob/ob mice, whereas after leptin treatment, RR and Vt decreased significantly. Leptin deficiency abolishes the response to hyperoxia, which is restored by leptin replacement. Thus, leptin seems to be influential for a competent peripheral chemoreceptor function.

引用

页码：559 / 570

页数：12

共 29 条

[1] Leptin regulates GH gene expression and secretion and nitric oxide production in pig pituitary cells [J].