Analysis of MGEA5 on 10q24.1-q24.3 encoding the β-O-linked N-acetylglucosaminidase as a candidate gene for type 2 diabetes mellitus in Pima Indians

被引：30

作者：

Farook, VS ^{[1
]}

Bogardus, C ^{[1
]}

Prochazka, M ^{[1
]}

机构：

[1] NIDDKD, Clin Diabet & Nutr Sect, Phoenix Epidemiol & Clin Res Branch, NIH, Phoenix, AZ 85016 USA

来源：

MOLECULAR GENETICS AND METABOLISM | 2002年 / 77卷 / 1-2期

关键词：

MGEA5; O-GlcNAcase; O-GlcNAc; type 2 diabetes mellitus; candidate gene; single nucleotide polymorphism; chromosome; 10q24; Pima Indians;

D O I：

10.1016/S1096-7192(02)00127-0

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Several diseases including type 2 diabetes mellitus (T2DM) are associated with abnormal O-glycosylation of proteins. beta-O-linked N-acetylglucosaminidase (O-GlcNAcase) encoded by MGEA5 on 10g24.1-q24.3 removes N-acetylglucosamine (O-GlcNAc), and we investigated this locus in Pima Indians who have the world's highest prevalence of T2DM. We detected two variants but there was no association with parameters of insulin resistance or diabetes in similar to1300 Pimas. We conclude that mutations in MGEA5 are unlikely to contribute to T2DM in this population. (C) 2002 Elsevier Science (USA). All rights reserved.

引用

页码：189 / 193

页数：5

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