The role of low-grade inflammation and metabolic flexibility in aging and nutritional modulation thereof: A systems biology approach

被引：74

作者：

Calcada, Duke ^{[1
,2
]}

Vianello, Dario ^{[3
]}

Giampieri, Enrico ^{[4
]}

Sala, Claudia ^{[4
]}

Castellani, Gastone ^{[4
]}

de Graaf, Albert ^{[1
]}

Kremer, Bas ^{[1
]}

van Ommen, Ben ^{[1
]}

Feskens, Edith ^{[2
]}

Santoro, Aurelia ^{[3
]}

Franceschi, Claudio ^{[3
,5
]}

Bouwman, Jildau ^{[1
]}

机构：

[1] TNO, Microbiol & Syst Biol Grp, NL-3704 HE Zeist, Netherlands

[2] Wageningen Univ, Dept Human Nutr, NL-6700 AP Wageningen, Netherlands

[3] Univ Bologna, Dept Expt Diagnost & Specialty Med, I-40126 Bologna, Italy

[4] Univ Bologna, Dept Phys & Astron, I-40127 Bologna, Italy

[5] Univ Bologna, Interdepartmental Ctr L Galvani CIG, I-40126 Bologna, Italy

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 2014年 / 136卷

关键词：

Inflammaging; Metabolic flexibility; Nutrition; Systems biology; Mathematical model; NF-KAPPA-B; MICROARRAY EXPERIMENT MIAME; MINIMUM INFORMATION; QUANTITATIVE-ANALYSIS; INTERACTION NETWORKS; INNATE IMMUNITY; T-CELLS; DATABASE; MODEL; PROTEOMICS;

D O I：

10.1016/j.mad.2014.01.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Aging is a biological process characterized by the progressive functional decline of many interrelated physiological systems. In particular, aging is associated with the development of a systemic state of low-grade chronic inflammation (inflammaging), and with progressive deterioration of metabolic function. Systems biology has helped in identifying the mediators and pathways involved in these phenomena, mainly through the application of high-throughput screening methods, valued for their molecular comprehensiveness. Nevertheless, inflammation and metabolic regulation are dynamical processes whose behavior must be understood at multiple levels of biological organization (molecular, cellular, organ, and system levels) and on multiple time scales. Mathematical modeling of such behavior, with incorporation of mechanistic knowledge on interactions between inflammatory and metabolic mediators, may help in devising nutritional interventions capable of preventing, or ameliorating, the age-associated functional decline of the corresponding systems. (C) 2014 The Authors. Published by Elsevier Ireland Ltd. All rights reserved.

引用

页码：138 / 147

页数：10

共 136 条

[1]

A systems biology approach to nutritional immunology - Focus on innate immunity [J].

Afacan, Nicole J. ;

Fjell, Christopher D. ;

Hancock, Robert E. W. .

MOLECULAR ASPECTS OF MEDICINE, 2012, 33 (01) :14-25

[2]

Aguda B., 2008, Models of cellular regulation

[3]

Role of inflammatory mechanisms in pathogenesis of type 2 diabetes mellitus [J].

Akash, Muhammad Sajid Hamid ;

Rehman, Kanwal ;

Chen, Shuqing .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2013, 114 (03) :525-531

[4]

Alberghina L., 2005, TOPICS CURRENT GENET, V13

[5]

Understanding Modularity in Molecular Networks Requires Dynamics [J].

Alexander, Roger P. ;

Kim, Philip M. ;

Emonet, Thierry ;

Gerstein, Mark B. .

SCIENCE SIGNALING, 2009, 2 (81) :pe44

[6]

Aging is associated with circulating cytokine dysregulation [J].

Alvarez-Rodriguez, Lorena ;

Lopez-Hoyos, Marcos ;

Munoz-Cacho, Pedro ;

Manuel Martinez-Taboada, Victor .

CELLULAR IMMUNOLOGY, 2012, 273 (02) :124-132

[7]

Alves R, 2008, BIOTECHNOL GENET ENG, V25, P1

[8]

[Anonymous], 2001, Foundations of Systems Biology

[9]

[Anonymous], BMJ

[10]

Reorganizing the protein space at the Universal Protein Resource (UniProt) [J].

Apweiler, Rolf ;

Martin, Maria Jesus ;

O'Donovan, Claire ;

Magrane, Michele ;

Alam-Faruque, Yasmin ;

Antunes, Ricardo ;

Casanova, Elisabet Barrera ;

Bely, Benoit ;

Bingley, Mark ;

Bower, Lawrence ;

Bursteinas, Borisas ;

Chan, Wei Mun ;

Chavali, Gayatri ;

Da Silva, Alan ;

Dimmer, Emily ;

Eberhardt, Ruth ;

Fazzini, Francesco ;

Fedotov, Alexander ;

Garavelli, John ;

Castro, Leyla Garcia ;

Gardner, Michael ;

Hieta, Reija ;

Huntley, Rachael ;

Jacobsen, Julius ;

Legge, Duncan ;

Liu, Wudong ;

Luo, Jie ;

Orchard, Sandra ;

Patient, Samuel ;

Pichler, Klemens ;

Poggioli, Diego ;

Pontikos, Nikolas ;

Pundir, Sangya ;

Rosanoff, Steven ;

Sawford, Tony ;

Sehra, Harminder ;

Turner, Edward ;

Wardell, Tony ;

Watkins, Xavier ;

Corbett, Matt ;

Donnelly, Mike ;

van Rensburg, Pieter ;

Goujon, Mickael ;

McWilliam, Hamish ;

Lopez, Rodrigo ;

Xenarios, Ioannis ;

Bougueleret, Lydie ;

Bridge, Alan ;

Poux, Sylvain ;

Redaschi, Nicole .

NUCLEIC ACIDS RESEARCH, 2012, 40 (D1) :D71-D75

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