DNA repair: Insights from urinary lesion analysis

被引：29

作者：

Cooke, MS ^{[1
]}

Evans, MD ^{[1
]}

Lunec, J ^{[1
]}

机构：

[1] Univ Leicester, Hosp Leicester NHS Trust, Leicester Royal Infirm,Oxidat Stress Grp, RKCSB,Dept Clin Biochem, Leicester LE2 7LX, Leics, England

来源：

FREE RADICAL RESEARCH | 2002年 / 36卷 / 09期

关键词：

urine; oxidative DNA damage; 8-oxo-2 '-deoxyguanosine; antibodies; repair;

D O I：

10.1080/1071576021000006635

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Due to various confounding factors, namely dietary contribution and cell death, measurement of urinary 8-oxo-2'-deoxyguanosine (8-oxodG) has long been considered to be no more than a marker of generalised oxidative stress. Indeed, the action of no single enzyme has been reported to excise 8-oxodG from DNA. However, analysis of recent research has suggested that these confounders may be circumvented, which, combined from work from the authors' laboratory, indicates that urinary 8-oxodG has the potential to become a most important marker of oxidative damage to, and repair of, DNA.

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收藏

页码：929 / 932

页数：4

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