CD95 (Fas) may control the expansion of activated T cells after elimination of bacteria in murine listeriosis

被引:24
作者
Fuse, Y
Nishimura, H
Maeda, K
Yoshikai, Y
机构
[1] NAGOYA UNIV,SCH MED,DIS MECHANISM & CONTROL RES INST,LAB HOST DEF & GERMFREE LIFE,SHOWA KU,NAGOYA,AICHI 466,JAPAN
[2] NAGOYA UNIV,BRANCH HOSP,DEPT INTERNAL MED,NAGOYA,AICHI,JAPAN
关键词
D O I
10.1128/IAI.65.5.1883-1891.1997
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
CD95 (Fas) is known to mediate activation-induced T-cell death by apoptosis. To understand the role of CD95 during the course of bacterial infection, we examined the kinetics of alpha beta and gamma delta T cells in the peritoneal cavities and fivers of 5-week-old CD95-defective MRL/lpr mice after an intraperitoneal infection with Listeria monocytogenes. The number of bacteria in the spleen decreased to an undetectable level by day 10 after infection with 7 x 10(3) Listeria cells similar to the number in MRL/+/+ mice. The number of alpha beta T cells expressing CD44 and CD95 reached a maximum in the peritoneal cavity on day 6 after listerial infection and thereafter decreased gradually in MRL/+/+ mice, whereas CD44(+) alpha beta T cells without CD95 expression continued to increase throughout the course of listerial infection in MRL/lpr mice. Freshly isolated T cells from MRL/+/+ mice infected,vith L. monocytogenes 10 days previously showed DNA fragmentation with apoptosis, whereas such fragmentation was not prominent in T cells from infected MRL/lpr mice. In correlation with the increased number of CD44(+) alpha beta T cells, Listeria-specific T-cell proliferation of peritoneal exudate cells was significantly greater in MRL/lpr mice than in MRL/+/+ mice on day 10 after listerial infection. In contrast to alpha beta T cells, gamma delta T cells increased in number only transiently in the peritoneal. cavity and liver after listerial infection in both MRL/lpr mice and MRL/+/+ mice. These results suggest that CD95-mediated cell death with apoptosis may be involved in termination of the alpha beta-T-cell-mediated immune response after the battle against L. monocytogenes has been won, whereas gamma delta T cells may undergo apoptosis independently of CD95 during the course of listerial infection.
引用
收藏
页码:1883 / 1891
页数:9
相关论文
共 58 条
[1]   ABERRANT TRANSCRIPTION CAUSED BY THE INSERTION OF AN EARLY TRANSPOSABLE ELEMENT IN AN INTRON OF THE FAS ANTIGEN GENE OF LPR MICE [J].
ADACHI, M ;
WATANABEFUKUNAGA, R ;
NAGATA, S .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (05) :1756-1760
[2]   DEVELOPMENTAL ARREST OF NK1.1(+) T-CELL ANTIGEN RECEPTOR (TCR)-ALPHA/BETA(+) T-CELLS AND EXPANSION OF NK1.1(+) TCR-GAMMA/DELTA(+) T-CELL DEVELOPMENT IN CD3-ZETA-DEFICIENT MICE [J].
ARASE, H ;
ONO, S ;
ARASE, N ;
PARK, SY ;
WAKIZAKA, K ;
WATANABE, H ;
OHNO, H ;
SAITO, T .
JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 182 (03) :891-895
[3]   EXPRESSION OF SYSTEMIC PROTECTION AND DELAYED-TYPE HYPERSENSITIVITY TO LISTERIA-MONOCYTOGENES IS MEDIATED BY DIFFERENT T-CELL SUBSETS [J].
BALDRIDGE, JR ;
BARRY, RA ;
HINRICHS, DJ .
INFECTION AND IMMUNITY, 1990, 58 (03) :654-658
[4]  
BOSSU P, 1993, J IMMUNOL, V151, P7233
[5]   CD44 IS NECESSARY FOR OPTIMAL CONTACT ALLERGIC RESPONSES BUT IS NOT REQUIRED FOR NORMAL LEUKOCYTE EXTRAVASATION [J].
CAMP, RL ;
SCHEYNIUS, A ;
JOHANSSON, C ;
PURE, E .
JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (02) :497-507
[6]  
CONLAN JW, 1991, J EXP MED, V174, P471
[7]   AUTOCRINE T-CELL SUICIDE MEDIATED BY APO-1/(FAS/CD95) [J].
DHEIN, J ;
WALCZAK, H ;
BAUMLER, C ;
DEBATIN, KM ;
KRAMMER, PH .
NATURE, 1995, 373 (6513) :438-441
[8]   THE FAS PROTEIN IS EXPRESSED AT HIGH-LEVELS ON CD4+CD8+ THYMOCYTES AND ACTIVATED MATURE LYMPHOCYTES IN NORMAL MICE BUT NOT IN THE LUPUS-PRONE STRAIN, MRL LPR/LPR [J].
DRAPPA, J ;
BROT, N ;
ELKON, KB .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (21) :10340-10344
[9]  
FARR AG, 1979, J IMMUNOL, V122, P2395
[10]   DIFFERENTIAL PRODUCTION OF INTERFERON-GAMMA AND INTERLEUKIN-4 IN RESPONSE TO TH1-STIMULATING AND TH2-STIMULATING PATHOGENS BY GAMMA-DELTA T-CELLS IN-VIVO [J].
FERRICK, DA ;
SCHRENZEL, MD ;
MULVANIA, T ;
HSIEH, B ;
FERLIN, WG ;
LEPPER, H .
NATURE, 1995, 373 (6511) :255-257