Further evidence for a link between melarsoprol resistance and P2 transporter function in African trypanosomes

被引：40

作者：

de Koning, HP

MacLeod, A

Barrett, MP

Cover, B

Jarvis, SM ^{[1
]}

机构：

[1] Univ Kent, Res Sch Biosci, Canterbury CT2 7NJ, Kent, England

[2] Univ Glasgow, Anderson Coll, Wellcome Unit Mol Parasitol, Glasgow G11 6NU, Lanark, Scotland

[3] Univ Glasgow, Inst Biomed & Life Sci, Div Infect & Immun, Glasgow G12 8QQ, Lanark, Scotland

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 2000年 / 106卷 / 01期

基金：

英国惠康基金;

关键词：

Trypanosoma brucei; drug resistance; purine transport; arsenicals;

D O I：

10.1016/S0166-6851(99)00206-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

[No abstract available]

引用

页码：181 / 185

页数：5

共 14 条

[1] The fall and rise of sleeping sickness [J].

Barrett, MP .

LANCET, 1999, 353 (9159) :1113-1114

[2] A DIAMIDINE-RESISTANT TRYPANOSOMA-EQUIPERDUM CLONE CONTAINS A P2 PURINE TRANSPORTER WITH REDUCED SUBSTRATE AFFINITY [J].

BARRETT, MP ;

ZHANG, ZQ ;

DENISE, H ;

GIROUD, C ;

BALTZ, T .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1995, 73 (1-2) :223-229

[3] A single locus minisatellite sequence which distinguishes between Trypanosoma brucei isolates [J].

Barrett, MP ;

MacLeod, A ;

Tovar, J ;

Sweetman, JP ;

Tait, A ;

LePage, RWF ;

Melville, SE .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1997, 86 (01) :95-99

[4] CHARACTERIZATION OF PENTAMIDINE-RESISTANT TRYPANOSOMA-BRUCEI-BRUCEI [J].

BERGER, BJ ;

CARTER, NS ;

FAIRLAMB, AH .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1995, 69 (02) :289-298

[5]

CARTER NS, 1995, J BIOL CHEM, V270, P28153, DOI 10.1074/jbc.270.47.28153

[6] ARSENICAL-RESISTANT TRYPANOSOMES LACK AN UNUSUAL ADENOSINE TRANSPORTER [J].

CARTER, NS ;

FAIRLAMB, AH .

NATURE, 1993, 361 (6408) :173-176

[7] Characterization of a nucleoside/proton symporter in procyclic Trypanosoma brucei brucei [J].

de Koning, HP ;

Watson, CJ ;

Jarvis, SM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (16) :9486-9494

[8] Purine nucleobase transport in bloodstream forms of Trypanosoma brucei brucei is mediated by two novel transporters [J].

deKoning, HP ;

Jarvis, SM .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1997, 89 (02) :245-258

[9] THE INTERACTION OF ARSENICAL DRUGS WITH DIHYDROLIPOAMIDE AND DIHYDROLIPOAMIDE DEHYDROGENASE FROM ARSENICAL RESISTANT AND SENSITIVE STRAINS OF TRYPANOSOMA-BRUCEI-BRUCEI [J].

FAIRLAMB, AH ;

SMITH, K ;

HUNTER, KJ .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1992, 53 (1-2) :223-231

[10] CHARACTERIZATION OF MELARSEN-RESISTANT TRYPANOSOMA-BRUCEI-BRUCEI WITH RESPECT TO CROSS-RESISTANCE TO OTHER DRUGS AND TRYPANOTHIONE METABOLISM [J].

FAIRLAMB, AH ;

CARTER, NS ;

CUNNINGHAM, M ;

SMITH, K .

MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 1992, 53 (1-2) :213-222

← 1 2 →