Catalytic enantioselective alkylation of benzaldehyde with diethylzinc using chiral nonracemic (thio)-phosphoramidates

被引：36

作者：

Hulst, R ^{[1
]}

Heres, H ^{[1
]}

Fitzpatrick, K ^{[1
]}

Peper, NCMW ^{[1
]}

Kellogg, RM ^{[1
]}

机构：

[1] UNIV GRONINGEN,GRONINGEN CTR CATALYSIS & SYNTH,DEPT ORGAN & MOL INORGAN CHEM,NL-9747 AG GRONINGEN,NETHERLANDS

来源：

TETRAHEDRON-ASYMMETRY | 1996年 / 7卷 / 09期

关键词：

D O I：

10.1016/0957-4166(96)00355-2

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Two chiral nonracemic gamma-amino alcohols, ephedrine thiol and the corresponding (thio)-phosphoramidates have been examined as catalysts for the enantioselective alkylation of benzaldehyde by diethylzinc. Addition of titanium tetraisopropoxide increases the yield as well as the enantioselectivity; 1-phenyl-propanol is obtained in up to 98% yield and e.e. Copyright (C) 1996 Published by Elsevier Science Ltd

引用

页码：2755 / 2760

页数：6

共 28 条

[1] ENANTIOSELECTIVE ADDITION OF DIETHYLZINC TO BENZALDEHYDE IN THE PRESENCE OF EPHEDRINE DERIVATIVES [J].