Transient increases of histamine H1 and H2 receptor mRNA levels in the rat striatum after the chronic administration of methamphetamine

被引:8
作者
Kubota, Y
Ito, C
Kuramasu, A
Sato, M
Watanabe, T
机构
[1] Tohoku Univ, Dept Pharmacol, Grad Sch Med, Aoba Ku, Sendai, Miyagi 9808575, Japan
[2] Tohoku Univ, Dept Psychiat, Grad Sch Med, Sendai, Miyagi 9808574, Japan
关键词
methamphetamine; H-1; receptor; H-2; semi-quantitative reverse transcription-polymerase chain reaction; rat striatum;
D O I
10.1016/S0304-3940(99)00730-2
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
In our previous studies, we found that behavioral sensitization evoked by repeated administration of methamphetamine (METH) was suppressed by the activation of the histaminergic neuron system in the brain. In continuation of these studies, we measured the levels of H-1 and H-2 receptor mRNAs in the rat striatum by semi-quantitative reverse transcription-polymerase chain reaction. Seven days after the 21 consecutive administrations of METH (4 mg/kg, i.p.), the levels of both H-1 and H-2 receptor mRNAs in the rat striatum increased significantly. However, 1 and 14 days after the last administration, there were no significant changes in levels of either H-1 or H-2 receptor mRNA in the rat striatum. These transient increases of H-1 and H-2 receptor mRNAs may have some relation to chronic METH abuse and its withdrawal. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:37 / 40
页数:4
相关论文
共 20 条
[1]   Increased levels of extracellular dopamine in neostriatum and nucleus accumbens after histamine H1 receptor blockade [J].
Dringenberg, HC ;
de Souza-Silva, MA ;
Schwarting, RKW ;
Huston, JP .
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1998, 358 (04) :423-429
[2]   GENOMIC CLONING OF THE RAT HISTAMINE H-1 RECEPTOR [J].
FUJIMOTO, K ;
HORIO, Y ;
SUGAMA, K ;
ITO, S ;
LIU, YQ ;
FUKUI, H .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1993, 190 (01) :294-301
[3]   Effects of histamine agents on methamphetamine-induced stereotyped behavior and behavioral sensitization in rats [J].
Ito, C ;
Onodera, K ;
Watanabe, T ;
Sato, M .
PSYCHOPHARMACOLOGY, 1997, 130 (04) :362-367
[4]  
Ito C, 1996, J PHARMACOL EXP THER, V279, P271
[5]   The effect of methamphetamine on histamine level and histidine decarboxylase activity in the rat brain [J].
Ito, C ;
Onodera, K ;
Sakurai, E ;
Sato, M ;
Watanabe, T .
BRAIN RESEARCH, 1996, 734 (1-2) :98-102
[6]   NEURONAL HISTAMINE INHIBITS METHAMPHETAMINE-INDUCED LOCOMOTOR HYPERACTIVITY IN MICE [J].
ITOH, Y ;
NISHIBORI, M ;
OISHI, R ;
SAEKI, K .
NEUROSCIENCE LETTERS, 1984, 48 (03) :305-309
[7]  
LANGE W R, 1986, Advances in Alcohol and Substance Abuse, V5, P71
[8]   Postnatal expression of H1-receptor mRNA in the rat brain:: correlation to L-histidine decarboxylase expression and local upregulation in limbic seizures [J].
Lintunen, M ;
Sallmen, T ;
Karlstedt, K ;
Fukui, H ;
Eriksson, KS ;
Panula, P .
EUROPEAN JOURNAL OF NEUROSCIENCE, 1998, 10 (07) :2287-2301
[9]   QUANTIFICATION OF MESSENGER-RNA BY NONRADIOACTIVE RT-PCR AND CCD IMAGING-SYSTEM [J].
NAKAYAMA, H ;
YOKOI, H ;
FUJITA, J .
NUCLEIC ACIDS RESEARCH, 1992, 20 (18) :4939-4939
[10]   NEUROPHARMACOLOGY OF THE HISTAMINERGIC NEURON SYSTEM IN THE BRAIN AND ITS RELATIONSHIP WITH BEHAVIORAL-DISORDERS [J].
ONODERA, K ;
YAMATODANI, A ;
WATANABE, T ;
WADA, H .
PROGRESS IN NEUROBIOLOGY, 1994, 42 (06) :685-702