Clinical correlates and cognitive underpinnings of verbal fluency impairment after chronic subthalamic stimulation in Parkinson's disease

被引：77

作者：

De Gaspari, D.

Siri, C.

Di Gioia, M.

Antonini, A.

Isella, V. ^{[1
]}

Pizzolato, A.

Landi, A.

Vergani, F.

Gaini, S. M.

Appollonio, I. M.

Pezzoli, G.

机构：

[1] Univ Milan, Neurol Sect, S Gerardo Hosp, DNTB, Monza, Italy

[2] Univ Milan, Neurosurg Sect, S Gerardo Hosp, DNTB, Monza, Italy

[3] Ctr Parkinsons Dis, Dept Neurociencias, Ist Clin Perfezionamento, Milan, Italy

来源：

PARKINSONISM & RELATED DISORDERS | 2006年 / 12卷 / 05期

关键词：

deep brain stimulation; verbal fluency; Parkinson's disease; clustering and switching;

D O I：

10.1016/j.parkreldis.2006.01.001

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A decline in verbal fluency is the most consistent neuropsychological sequela of deep brain stimulation (DBS) for Parkinson's disease. We assessed clinical correlates and switching and clustering subcomponents in 26 parkinsonians undergoing subthalamic DBS. Post-surgical motor improvement was accompanied by worsening at both letter and category fluency tasks. Total number of words and switches decreased, while average cluster size was unchanged. Worsening tended to be prominent in patients with baseline poorer cognitive status and more depressed mood. Impairment of shifting suggests prefrontal dysfunction, possibly due to disruption of fronto-striatal circuits along the surgical trajectory and/or to high frequency stimulation itself. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：289 / 295

页数：7

共 52 条

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Effects of bilateral subthalamic stimulation on cognitive function in Parkinson disease [J].