Frailty

被引：117

作者：

Morley, John E.

Haren, Matthew T.

Rolland, Yves

Kim, Moon Jong

机构：

[1] St Louis Univ, Sch Med, Div Geriatr Med, St Louis, MO 63104 USA

[2] Vet Adm Med Ctr, GRECC, St Louis, MO 63125 USA

[3] Hop Grave Casselardit, Dept Internal Med & Geriatr, F-31300 Toulouse, France

[4] Pochon CHA Univ, Dept Family Med, Seoul 463712, South Korea

来源：

MEDICAL CLINICS OF NORTH AMERICA | 2006年 / 90卷 / 05期

关键词：

D O I：

10.1016/j.mcna.2006.05.019

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Frailty is a condition that now can be objectively defined by the Fried criteria. Frail people are at risk for rapid deterioration when exposed to stressful events. The causes of frailty are multifactorial and include sarcopenia, protein energy malnutrition, pain, and various disease processes, such as anemia, diabetes mellitus, depression, and congestive heart failure. At the pathophysiologic level, elevated proinflammatory cytokine, low vitamin D, and low testosterone levels (in men and possibly women) all play a role in the genesis of frailty.

引用

页码：837 / +

页数：12

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