30 Years of NF-κB: A Blossoming of Relevance to Human Pathobiology

被引：2276

作者：

Zhang, Qian ^{[1
]}

Lenardo, Michael J. ^{[2
,3
]}

Baltimore, David ^{[4
]}

机构：

[1] Sidra Med & Res Ctr, Dept Translat Med, Doha, Qatar

[2] NIAID, Mol Dev Immune Syst Sect, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[3] NIAID, NIAID Clin Genom Program, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[4] CALTECH, Div Biol & Biol Engn, Pasadena, CA 91125 USA

来源：

CELL | 2017年 / 168卷 / 1-2期

关键词：

HERPES-SIMPLEX ENCEPHALITIS; HYPOHIDROTIC ECTODERMAL DYSPLASIA; COMMON VARIABLE IMMUNODEFICIENCY; PYOGENIC BACTERIAL-INFECTIONS; INHERITED CARD9 DEFICIENCY; BETA-BINDING PROTEIN; LYMPHOCYTE-ACTIVATION; ANTIGEN-RECEPTOR; IMMUNE-SYSTEM; FRONTOMETAPHYSEAL DYSPLASIA;

D O I：

10.1016/j.cell.2016.12.012

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

NF-kappa B was discovered 30 years ago as a rapidly inducible transcription factor. Since that time, it has been found to have a broad role in gene induction in diverse cellular responses, particularly throughout the immune system. Here, we summarize elaborate regulatory pathways involving this transcription factor and use recent discoveries in human genetic diseases to place specific proteins within their relevant medical and biological contexts.

引用

页码：37 / 57

页数：21

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